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Pharmacology > Drug reactions > Flashcards

Drug reactions Flashcards

1
Q

Drugs that cause hypothyroidism

A

Lithium

Amiodarone

Sulfonamides

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2
Q

Drugs that cause acute hepatitis and jaundice

A

Erythromycin

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3
Q

Drugs that cause diarrhea

A

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose

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4
Q

Drugs that cause hepatic necrosis

A

Rifampin, isoniazid, pyrazinamide, statins, fibrates

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5
Q

Drugs that cause pancreatitis

A

Didanosine

Corticosteroids

Alcohol

Valproic Acid

Azathioprine

Diuretics

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6
Q

Drugs that cause agranulocytosis

A 
Ganciclovir
Clozapine
Carbamazepine
Colchicine
Methimazole
Propylthiouracil
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7
Q

Drugs that cause hyperglycemia

A 
Tacrolimus
Protease inhibitors
Niacin
HCTZ
Corticosteroids
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8
Q

Drugs that cause aplastic anemia

A

Carbamazepine, Methimazole, Propylthiouracil, NSAIDs, Benzene, Chloramphenicol

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9
Q

Hemolytic anemia

A

Methyldopa, PCN

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10
Q

Drugs that cause hemolysis with G6PD deficiency

A

Hemolysis IS D PAIN

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin
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11
Q

Drugs that cause megaloblastic anemia

A

Having a BLAST with PMS

Phenytoin
Methotrexate
Sulfa drugs

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12
Q

Drugs that cause fat redistribution

A

Protease inhibitors, Glucocorticoids

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13
Q

Drugs that cause gingival hyperplasia

A

Phenytoin, CCBs, Cyclosporine

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14
Q

Drugs that cause gout

A 
Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine

“Painful Tophi and Feet Need Care”

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15
Q

Drugs that cause myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, IFN-alpha, penicillamine, statins, glucocorticoids

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16
Q

Drugs that cause photosensitivity

A

Sulfonamides
Amiodarone
Tetracyclines
5-FU

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17
Q

Drugs that cause Stevens-Johnson

A

Anti-epileptics
Allopurinol
Sulfa drugs
PCN

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18
Q

Drugs that cause SLE-like syndrome

A 
Sulfa drugs
Hydralazine
Isoniazid
Procainamide
Phenytoin
Etanercept
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19
Q

Drugs that cause tendon/cartilage damage

A

Fluoroquinolones

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20
Q

Drugs that cause seizures

A

Isoniazid (B6 def)
Bupropion
Imipenem/cilastatin
Enflurane

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21
Q

Drugs that cause DI

A

Lithium

Demeclocycline

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22
Q

Drugs that cause hemorrhagic cystitis

A

Cyclophosphamide
Ifosfamide

both chemo drugs

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23
Q

Drugs that cause interstitial nephritis

A

Methicillin, NSAIDs, Furosemide

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24
Q

Drugs that cause SIADH

A

“Can’t Concentrate Serum Sodium”

Carbamazepine
Cyclophosphamide
SSRIs

Also: chlorpropamide (sulfonylurea), lung dz (pna, tb, ventilator use)

25
Q

Drugs that cause pulmonary fibrosis

A

“Breathing Air Badly from Medications”

Bleomycin
Amiodarone
Busulfan
Methotrexate

(chemo drugs, except amiodarone)

26
Q

Drugs that cause disulfiram like rxns

A 
Metronidazole
Cephalosporins
Griseofulvin
Procarbazine
Sulfonylureas
27
Q

Reversal of thrombolytics (eg TPA)

A

Aminocaproic acid

28
Q

Heparin reversal

A

Protamine sulfate

29
Q

Drugs that cause aplastic anemia

A

Carbamazepine, Methimazole, Propylthiouracil, NSAIDs, Benzene, Chloramphenicol

30
Q

Hemolytic anemia

A

Methyldopa, PCN

31
Q

Drugs that cause hemolysis with G6PD deficiency

A

Hemolysis IS D PAIN

Isoniazid
Sulfonamides
Dapsone
Primaquine
Aspirin
Ibuprofen
Nitrofurantoin
32
Q

Drugs that cause megaloblastic anemia

A

Having a BLAST with PMS

Phenytoin
Methotrexate
Sulfa drugs

33
Q

Drugs that cause fat redistribution

A

Protease inhibitors, Glucocorticoids

34
Q

Drugs that cause gingival hyperplasia

A

Phenytoin, CCBs, Cyclosporine

35
Q

Drugs that cause gout

A 
Pyrazinamide
Thiazides
Furosemide
Niacin
Cyclosporine

“Painful Tophi and Feet Need Care”

36
Q

Drugs that cause myopathy

A

Fibrates, niacin, colchicine, hydroxychloroquine, IFN-alpha, penicillamine, statins, glucocorticoids

37
Q

Drugs that cause photosensitivity

A

Sulfonamides
Amiodarone
Tetracyclines
5-FU

38
Q

Drugs that cause Stevens-Johnson

A

Anti-epileptics
Allopurinol
Sulfa drugs
PCN

39
Q

Drugs that cause SLE-like syndrome

A 
Sulfa drugs
Hydralazine
Isoniazid
Procainamide
Phenytoin
Etanercept
40
Q

Drugs that cause tendon/cartilage damage

A

Fluoroquinolones

41
Q

Drugs that cause seizures

A

Isoniazid (B6 def)
Bupropion
Imipenem/cilastatin
Enflurane

42
Q

Drugs that cause DI

A

Lithium

Demeclocycline

43
Q

Drugs that cause hemorrhagic cystitis

A

Cyclophosphamide
Ifosfamide

both chemo drugs

44
Q

Drugs that cause interstitial nephritis

A

Methicillin, NSAIDs, Furosemide

45
Q

Drugs that cause SIADH

A

“Can’t Concentrate Serum Sodium”

Carbamazepine
Cyclophosphamide
SSRIs

46
Q

Drugs that cause pulmonary fibrosis

A

“Breathing Air Badly from Medications”

Bleomycin
Amiodarone
Busulfan
Methotrexate

(chemo drugs, except amiodarone)

47
Q

Drugs that cause disulfiram like rxns

A 
Metronidazole
Cephalosporins
Griseofulvin
Procarbazine
Sulfonylureas
48
Q

Reversal of thrombolytics (eg TPA)

A

Aminocaproic acid

49
Q

Heparin reversal

A

Protamine sulfate

50
Q

Drugs that cause hypocalcemia

A

bisphosphonates, loop diuretics, foscarnet (also causes hypokalemia, hypomagnesemia, hypophosphatemia)

51
Q

Daptomycin side effect?

A

rhabdomyolysis

lipopeptide used to treat G-

52
Q

Gingival hyperplasia is a side effect of ____

A

phenytoin (in 50% of pts)

53
Q

phenytoin AEs

A

CNS sx (ataxia, nystagmus)

gingival hyperplasia, coarsening of facial features, hirsutism

interferes with folic acid metabolism –> megaloblastic anemia

P450 inducer

54
Q

Lithium AEs

A

neuromuscular excitability, nephrogenic DI, hypothyroidism, cardiac conduction defects

55
Q

Isoniazid - severe AE?

A

hepatitis

56
Q

Drug that can cause pancreatitis?

A

didanosine (NRTI)

57
Q

Drugs that cause acute tubular necrosis

A

aminoglycosides, lead, cisplatin, radiocontrast media, amphotericin B, foscarnet

58
Q

Drugs that can precipitate in kidney tubules and cause obstruction?

A

sulfonamides, methotrexate, acyclovir, triamterene

59
Q

Toxicity of hydroxychloroquine?

A

irreversible retinopathy

long-term users (eg mild RA, SLE) should have regular ophtho exams

Pharmacology (4 decks)

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