Drug Profiles Flashcards

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1
Q

Adenosine/Adenocard classification

A

Antiarrhythmic

Endogenous Nucleoside

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2
Q

Adenosine/Adenocard MOA

A

Slows conduction time through AV node

slows sinus rate

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3
Q

Adenosine/Adenocard Indications

A

SVT.

Wide complex tachycardia of uncertain origin unresponsive to lidocaine.

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4
Q

Adenosine/Adenocard contraindications

A

Sick Sinus Syndrome.
2nd/3rd* AV blocks - except in patients with pacemakers.
Known A-fib/A-flutter.
Pregnancy.

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5
Q

Adenosine/Adenocard adverse reactions

A

Transient dysrhythmias (asystole, bradycardia, PVC’s, V-tach)

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6
Q

Adenosine/Adenocard routes of administration

A

Recommended IV site is antecubital fossa.

IV/IO only.

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7
Q

Adenosine/Adenocard Adult dose

A

Initial: 12mg Rapid IV bolus over 1-3 sec followed by 20cc NS flush.
Repeat dose: 1x repeat only. Same as initial dose.

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8
Q

Adenosine/Adenocard Pediatric dose

A

Initial: 0.1mg/kg Rapid IV bolus with 2-3cc NS flush.
Repeat: 1x repeat only. .2mg/kg Rapid IV bolus with 2-3cc NS flush.

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9
Q

Adenosine/Adenocard onset of action

A

seconds

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10
Q

Adenosine/Adenocard special notes

A

Dysrhythmias may recur and appear in 55% of patients, lasting for a few seconds. Use cautiously in patients on theophylline and related methylxanthines, dipyridomole (Persantine), or carbamazepine (Tegretol).

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11
Q

Adenosine/Adenocard forms/packaging

A

Flip top vials 6mg/2ml (3mg per ml)
Prefilled syringe 6mg/2ml (3mg per ml)
Prefilled syringe 12mg/4ml

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12
Q

Adenosine/Adenocard AZ drug box supply

A

Paramedics: 5-6 vials (2+ 12mg doses)

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13
Q

Albuterol Sulfate/Proventil/Ventolin classification

A

Sympathomimetic

Brochodilator

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14
Q

Albuterol Sulfate/Proventil/Ventolin MOA

A

Stimulates Beta2 receptors in the smooth muscle of the bronchial tree

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15
Q

Albuterol Sulfate/Proventil/Ventolin Indications

A

Bronchospasm

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16
Q

Albuterol Sulfate/Proventil/Ventolin contraindications

A

Use caution in patients with diabetes, hyperthyroidism, and cerebrovascular disease
Tricyclic antidepressants
MAO inhibitors

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17
Q

Albuterol Sulfate/Proventil/Ventolin Adverse reactions

A
dysrhythmias
tachycardia
tremors
nervousness
N/V
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18
Q

Albuterol Sulfate/Proventil/Ventolin adult dose

A

2.5mg of premixed solution for inhalation (0.083%) via SVN. May repeat as needed.

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19
Q

Albuterol Sulfate/Proventil/Ventolin pediatric dose

A

<40lbs, administer half of 0.083% premixed solution by adding 1-1.5ml NS to make 2.5-3cc and administer via SVN

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20
Q

Albuterol Sulfate/Proventil/Ventolin route of administration

A

nebulized via mouth piece or in-line mask, or nebulized through ET/NT in-line

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21
Q

Albuterol Sulfate/Proventil/Ventolin onset of action

A

5-15 minutes

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22
Q

Albuterol Sulfate/Proventil/Ventolin AZ drug box supply

A

Paramedics: 2-6 independant doses

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23
Q

Albuterol Sulfate/Proventil/Ventolin dosage forms/packaging

A

2.5mg albuterol premixed solution tube

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24
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC classification

A

analgesic (pain relief)
antipyretic (fever reducing)
anti-inflammatory

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25
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC MOA

A

aspirin blocks thromboxane A2 (a potent platelet aggregate) and decreases platelet aggregation

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26
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC indications

A

chest pain

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27
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC contraindications

A

bleeding ulcer
hemorrhagic states
hemophilia
known hypersensitivity to salicylates or other non-steroidal anti-inflammatories

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28
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC adverse reactions

A

anaphylactic reaction in sensitive patients have occurred

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29
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC adult dose

A

324mg PO (4 x 81mg pediatric chewable tabs)

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30
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC pediatric dose

A

not recommended for peds

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31
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC onset of action

A

20-30 minutes

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32
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC special notes

A

baby ASA is heat and light sensitive. The odor of acetic acid (vinegar-like smell) indicates degradation of product.

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33
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC dosage forms

A

81mg-325mg tablets

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34
Q

acetylsalicylic acid/aspirin/ASA/Bufferin/Anacin/APC AZ drug box supply

A

Paramedics: 36 to 100 tablets

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35
Q

atropine sulfate/Atropine classification

A

parasympatholytic (decreases parasympathetic nervous system - the PSNS slows heart rate among other things)
antimuscarinic
parasympathetic antagonist

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36
Q

atropine sulfate/Atropine MOA

A

competitively blocks acetylcholine (Ach) at muscarinic receptor sites

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37
Q

atropine sulfate/Atropine indications

A
symptomatic bradycardia (sinus, junctional, & AV blocks)
Asystole (no longer in AHA or PFD guidelines)
PEA (no longer in AHA or PFD guidelines)
Organophosphate/Cholinergic poisonings
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38
Q

atropine sulfate/Atropine contraindications

A

glaucoma

acute narrow angle glaucoma (relative contraindication)

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39
Q

atropine sulfate/Atropine adverse reactions

A

tachydysrhythmias
exacerbation of glaucoma
precipitation of myocardial ischemia (insufficient blood flow to the heart)

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40
Q

atropine sulfate/Atropine adult dose

A

Symptomatic bradycardia: 0.5-1.0mg Rapid IVP every 3-5 minutes, to a total dose of 3mg.
Cholinergic/Organophosphate poisoning: 2.0-5.0mg IV. May repeat in 5 minutes. No max dose.

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41
Q

atropine sulfate/Atropine pediatric dose

A

Symptomatic bradycardia: 0.02mg/kg IV/IO.

May repeat once. Max dose: Child - 0.5mg. Adolescent - 1.0mg

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42
Q

atropine sulfate/Atropine routes of administration

A

IV/IO/ET

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43
Q

atropine sulfate/Atropine onset of action

A

1 minute

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44
Q

atropine sulfate/Atropine special notes

A

administering too small of doses or too slowly may result in paradoxical bradycardia.
Patient that describes their glaucoma as painful probably has acute narrow angle glaucoma.

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45
Q

atropine sulfate/Atropine dosage forms

A

1mg/10ml prefilled syringes

8mg/20ml multi-dose vial

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46
Q

atropine sulfate/Atropine AZ drug box supply

A
Paramedics: 4 x (1mg/10ml) prefilled syringes
1 x (8mg/20ml) multidose vial which is .4mg/ml.
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47
Q

ipratropium bromide/Atrovent classification

A

anticholinergic

bronchodilator

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48
Q

ipratropium bromide/Atrovent MOA

A

produces preferential dilation of the larger central airways

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49
Q

ipratropium bromide/Atrovent indications

A

bronchospasm

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50
Q

ipratropium bromide/Atrovent contraindications

A

hypersensitivity to ipratropium bromide or to atropine and its derivatives

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51
Q

ipratropium bromide/Atrovent adverse reactions

A
coughing
sputum increase
dizziness
tremors
nausea
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52
Q

ipratropium bromide/Atrovent administration notes

A

it is a safe and effective bronchodilator when used in conjunction with beta adrenergic bronchodilators (albuterol).

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53
Q

ipratropium bromide/Atrovent adult dose

A

2.5ml of a 0.02% solution via SVN may be used one time.

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54
Q

ipratropium bromide/Atrovent pediatric

A

2.5ml of a 0.02% solution via SVN may be added to each SVN treatment.

55
Q

ipratropium bromide/Atrovent routes of administration

A

nebulized via SVN

56
Q

ipratropium bromide/Atrovent onset of action

A

5-15 minutes

57
Q

ipratropium bromide/Atrovent special notes

A

may mix one unit dose vial of ipratropium with one unit dose vial of albuterol.
Should be kept out of light in foil pouch to avoid excessive humidity.

58
Q

ipratropium bromide/Atrovent dosage forms

A

inhalation solution: Unit dose vial is supplied as 0.02% clear, colorless solution containing 2.5ml, with 25 vials per foil pouch.

59
Q

ipratropium bromide/Atrovent AZ drug box supply

A

Paramedics: 2 - unit doses

60
Q

Bumetinide/Bumex indications

A

pulmonary edema

61
Q

Bumetinide/Bumex contraindications

A

Hypersensitivity, anuria, electrolyte deficiencies

62
Q

Bumetinide/Bumex adverse reactions

A
dizziness
headache
muscle cramps
hypotension
EKG changes
63
Q

Bumetinide/Bumex adult dose

A

0.5-1.0mg slwo IVP over 1-2 minutes, or IM

64
Q

Bumetinide/Bumex pediatric dose

A

not used for pediatrics

65
Q

40mg furosemide = how much bumetanide?

A

1mg bumetanide = 40mg furosemide

66
Q

Calcium Chloride inidications for field use

A

significant hypocalcemia or hyperkalemia
Calcium channel blocker OD.
Pre-treat for IV verapamil administration

67
Q

Calcium Chloride contraindications

A

hypercalcemia.

concurrent digoxin therapy (relative)

68
Q

Calcium Chloride adverse reactions

A

brady-asystolic arrest.

servere tissue necrosis if solution extravasates.

69
Q

Calcium Chloride adult dose

A

For hypocalcemia, calcium channel blocker OD, hyperkalemia, and hypermagnesemia:
5-10 ml (0.5-1gm) of 10% calcium chloride. May repeat in 10 minutes.
For verapamil pre-treatment:
3ml of 10% solution. May be repeated once.

70
Q

Calcium Chloride pediatric dose

A

For hypocalcemia, calcium channel blocker OD, hyperkalemia, and hypermagnesemia:

  1. 2ml/kg of a 10% solution infused slowly
    * May be diluted with 102ml of NS IV per ml of calcium chloride.
71
Q

Activated Charcoal/Charcoal/Actidose-aqua indications for field use

A

prehospital therapy of oral ingestion of toxic substances

72
Q

Activated Charcoal/Charcoal/Actidose-aqua contraindications

A

ingestion of caustics or hydrocarbons

73
Q

Activated Charcoal/Charcoal/Actidose-aqua adverse reactions

A

may provoke vomiting

74
Q

Activated Charcoal/Charcoal/Actidose-aqua adult dose

A

50grams, orally

75
Q

Activated Charcoal/Charcoal/Actidose-aqua pediatric dose

A

0.5-1g/kg

76
Q

Dextrose 50%/D50 indications for field use

A

ALOC
seizures
known hypoglycemia

77
Q

Dextrose 50%/D50 contraindications

A
stroke (unless documented hypoglycemia)
intracranial hemorrhage (relative)
78
Q

Dextrose 50%/D50 adverse reations

A

cerebral edema and intracranial hemorrhage in children when given IV undiluted.
Worsens elevated ICP
Extravasation leads to sever tissue necrosis

79
Q

Dextrose 50%/D50 adult dose

A

For hypoglycemia, ALOC, or seizures of uknown etiology:

25-50ml of D50 (12.5-25g, or .5-1AMP) IV

80
Q

Dextrose 50%/D50 pediatric dose

A

0.5-1g/kg (5-10cc/kg) of D10% solution, given slowly over a 20 minute period.
To make D10, waste 50ml of 250ml NS bag and add 50ml of D50. This makes D10 or 10g/ml.

81
Q

Dyphenhydramine HCL/Benadryl indications for field use

A

anaphylaxis (2nd line)
phenothiazine reactions (extrapyramidal symptoms)
antiemetic (anti nausea)

82
Q

Dyphenhydramine HCL/Benadryl contraindications

A

know hypersensitivity
newborn or premature infants; nursing mothers
caution with patients with glaucoma, acute narrow angle, stenosing or obstructive diseases of the GI tract, bronchial asthma, hyperthyroidism, cardiovascular disease or hypertension, older than 60 (all relative/benefit vs risk)

83
Q

Dyphenhydramine HCL/Benadryl adverse reactions

A

CV:hypotension, palpitations, arrhythmias, hemolytic anemia
Resp: anaphylaxis, thickening of bronchial secretions, tightness in chest, wheezing, nasal stuffiness
CNS: sedation, visual disturbances, seizures
GU/GI: urinary frequency or retention, vomiting
PEDS: In children, may cause paradoxical CNS excitation, seizure, palpitations, thickening of pronchial secretions.

84
Q

Dyphenhydramine HCL/Benadryl adult dose

A

Minor allergic RX: 25mg slow IVP or deep IM
Anaphylaxis: 50 mg slow IVP or deep IM
Extrapyramidal symptoms and antiemetic: 50mg IV or deep IM (dose should be individualized according to the needs and the patient response)

85
Q

Dyphenhydramine HCL/Benadryl pediatric dose

A

Allergy/Anaphylaxis: 1-2mg/kg slow IVP or deep IM

86
Q

Dopamine/Intropin indications for field use

A

sypmtomatic bradycardias
hemodynamically significant hypotension in the absence of hypovolemia
cardiogenic shock (post code)

87
Q

Dopamine/intropin contraindications

A

hypovolemic shock
pheochromocytoma
MAO inhibitors (Marplan, Nardil, or Parnate)

88
Q

Dopamine/intropin adverse reactions

A

tachyarrhythmias
precipitation of mycardial ischemia and/or MI
hypertension

89
Q

Dopamine/intropin adult dose

A

If premixed not carried, add 400mg to 250ml NS which = 1600mcg/ml. Start at 5mcg/kg/min (1 micro drop per min equals 1cc per hour)

90
Q

Dopamine/intropin pediatric dose

A

2-20 mcg/kg/min for circulatory shock or shock unresponsive to fluid administration.
To prepare infusion for small children: 6x body weight (kg) = mg added to make 100ml. With this mixture, 1ml/hr delivers 1mcg/kg/min.
Titrate to effect.

91
Q

Dopamine/intropin effects in 1-2mcg/kg/min range

A

1-2mcg/kg/min gets renal and mesenteric vasodilation

92
Q

Dopamine/intropin effects in 2-10mcg/kg/min range

A

2-10mcg/kg/min gets renal and mesenteric vasodilation with increased cardiac output, and a modest increase in Systemic Vascular Resistance (SVR)

93
Q

Dopamine/intropin effects in 10-20mcg/kg/min range

A

10-20mcg/kg/min range: peripheral vasoconstriction with marked increase in systemic vascular resistance, pulmonary vascular resistance, and further increase in preload

94
Q

Dopamine/intropin effects in >20mcg/kg/min range

A

> 20mcg/kg/min produces hemodynamic effects similar to norepinephrine, and may increase heart rate and O2 demand.

95
Q

Epi indications for field use

A

anaphylaxis
cardiac arrest (VT, pulseless VF, asystole, PEA)
severe bronchospasm - bronchiolitis, asthma, croup, stridor (NOT COPD)
bradycardia with hypotension

96
Q

Epi contraindications

A

none for cardiac arrest

97
Q

Epi adverse reactions

A

hypertension
ventricular dysrhythmias - tachycardia, angina
muscle tremors

98
Q

Epi adult dose

A

Asmtha/Anaphylaxis (age < 35): .3mg IM 1:1K
Cardiac Arrest: IV: 1mg 1:10K q 3-5min.
Cardiac Arrest: ET: 2-2.5mg 1:1K mixed with NS to equal 10ml)
Infusion: 2-10mcg/min IV

99
Q

Epi pediatric dose

A

Asthma/Anaphylaxis: .01mg/kg IM up to .5mg (.5ml) of 1:1k
Cardiac Arrest: IV: .01mg/kg 1:10K q 3-5min
Cardiac Arrest: ET: 01mg/kg 1:1K
Croup: or equal to 5y/o: 5mg 1:1K with 3cc NS SVN

100
Q

Furosemide/Lasix indications for field use

A

pulmonary edema

congestive heart failure (CHF)

101
Q

furosemide/Lasix contraindications

A

anuria (not urinating - relative)
hypovolemia
hypotension

102
Q

furosemide/Lasix adverse reactions

A

may exacerbate hypovolemia

hypokalemia

103
Q

furosemide/Lasix adult dose

A

If patient on oral lasix, give 2x daily oral amount. If not result in 20 minutes, double dose and repeat.
If patient not on oral lasix, .5-1mg/kg to a maximum of 2mg/kg (usually 20-40mg) IV slowly.

104
Q

furosemide/Lasix pediatric dose

A

1mg/kg IV slowly

105
Q

glucagon indications for field use

A

symptomatic hypoglycemia when IV access is delayed.

Beta blocker overdose.

106
Q

glucagon contraindications

A

known hypersensitivity.
Pheochromocytoma
Insulinoma

107
Q

glucagon adverse reactions

A

nausea/vomiting

108
Q

glucagon adult dose

A

1mg IM. May repeat in 8-10 minutes.

109
Q

glucagon pediatric dose

A

20kg/44lb: 1mg IM, may repeat in 8-10 minutes

110
Q

lidocaine HCl indications for field use

A

suppression of ventricular arrythmias (v-tach, lv-fib, PVC’s)
Prophylaxis against recurrence after conversion from V-tach of V-fib.
Frequent PVC’s (>6/min, 2 or more in a row, multiform, R-onT phenomenon)

111
Q

lidocaine HCl contraindications

A

known hypersensitivity
Do NOT treat ectopic beats if HR<60. They are probably compensating for the bradycardia. Instead, treat the bradycardia!

112
Q

lidocaine HCl adverse reactions

A

CV: May also cause SA nodal depression or conduction problems and hypotension in large doses, or if given too rapidly. Excessive doses in pediatric patient may produce myocardial and circulatory depression.
CNS: In large doses causes drowsiness, disorientation, paresthesias, decreases hearing acuity, muscle twitching, agitation, focal or generalized seizures.

113
Q

lidocaine HCl adult dose

A

Pulseless VF/VT or Antidysrhythmic/rhythm with pulse: Initial bolus of 1-1.5mg/kg IVP, then repeat at half initial dose q 5-10 minutes, to a total of 3mg/kg. An initial bolus of 1.5mg/kg may be given for cardia arrest situations. Following return of a spontaneous rhythm, initiate a drip of 2-4mg/min.
Reduce infusion by half for patients >70y/o or with liver disease.
Maintenance infusion: 2gm in 500NS premixed solution. Drip rate at 2-4mg/min using clock (1:15, 2:30, 3:45, 4:60)

114
Q

lidocaine HCl pediatric dose

A

Initial bolus: 1mg/kg. May repeat 1 time in 15 minutes for VF/Pulseless VT or in 15 minutes if used for refractory dysrhytmias with a pulse.
Infusion: 20-50 mcg/kg/min, prepared by adding 120mg (3cc) of 1gm/25ml (40mg/ml) solution to 97ml of NS, yielding 1200mcg/ml. 1ml/kg/hr delivers 20mcg/kg/min. 2.5ml/kg/hr delivers 50mcg/kg/min. Reduce to < or equal 20mcg/kg/min for children with low cardiac output, severe CHF, or compromised hepatic blood flow.
Infusion should be avoided unless infusion pump is available.

115
Q

magnesium sulfate indications for field use

A
torsade de pointes (first line drug)
VF/Pulseless VT refractory to lidocaine
pregnancy-induced hypertension (PIH, toxemia of pregnancy, pre-eclampsia and/or eclampsia)
severe bronchospasm (asthma only)
116
Q

magnesium sulfate contraindications

A

hypermagnesemia

Use cautiously in patients with impaired renal function and pre-existing heart blocks (relative)

117
Q

magnesium sulfate adverse reactions

A

CV: hypotension, flushing circulatory collapse, depressed cardiac function, heart block, asystole, smooth muscle relaxant (antihypertensive effects)
RESP: respiratory depression and/or paralysis may occur in both mother and/or infant during or up to 24 hours after the administration of Mag.
CNS: sweating, drowsiness, hypothermia, depressed reflexes pressing to flaccidity and paralysis which may occur in both mother and/or infant during the administration of or up to 24 hours after the administration of Mag.
GI: nausea
GU: mild diuretic
Metabolic: hypocalcemia, hypomagnesemia

118
Q

magnesium sulfate adult dose

A

VF/pulseless VT: 1-2g IV in 1-2min or dilute 1-2g in 50cc NS administered over 1-2min.
Torsade de pointes: 1-2g IV in 1-2min or dilute 1-2g in 50cc NS administered over 1-2min, then repeat same dose infused over 1hour.
Pregnancy induced hypertension/pre-eclampsia/eclampsia: 4-6g in 50cc NS over 20minutes
Bronchospasm: 2g in 50cc NS infused over 10minutes

119
Q

magnesium sulfate pediatric dose

A

bronchospasm: 25-50mg/kg in 50cc NS infused over 10 minutes (to a max of 2g)

120
Q

solu-medrol indications for field use

A

reactive airway disease.

Acute exacerbation of emphysema, chronic bronchitis, asthma, or anaphylaxis.

121
Q

solu-medrol contraindications

A

none

122
Q

solu-medrol adverse reactions

A

none from single dose

123
Q

solu-medrol adult dose

A

125mg IV

124
Q

solu-medrol pediatric dose

A

2.0mg/kg IV (up to 125mg)

125
Q

midazolam indications for field use

A

anti-convulsant.
sedation
management of acute agitation/treat causes first.
sedation for intubation.

126
Q

midazolam contraindications

A

hypersensitivity to midazolam

127
Q

midazolam adverse reactions

A

CV: hypotension, cardiac arrest, irregular or fast heart beat.
RESP: apnea, respiratory depression, respiratory arrest, hyperventilation, wheezing or difficulty in breathing, hiccups, coughing.
CNS: emergence delirium, muscle tremors, uncontrolled or jerky movements of body, unusual excitement, irritability or restlessness, dizziness, light-headed or feeling faint, prolonged drowsiness, headache.
GI: nausea/vomiting

128
Q

midazolam adult dose

A

2.5-5mg IV/IM SIVP over 1-2minutes. No more than 2.5mg at one time. Max dose of 20mg.
Seizures: 0.2mg/kg IM for status seizures if no IV access.

129
Q

midazolam pediatric dose

A

.1mg/kg slow IVP

Seizures: .2mg/kg IM for status seizures if no IV access.

130
Q

morphine sulfate indications for field use

A

analgesia (pain management), especially in patients with burns, MI, or renal colic

131
Q

morphine sulfate contraindications

A

respiratory depression

head injuries

132
Q

morphine sulfate adverse reactions

A

CV: brady or tachydysrhythmias, hypotension
RESP: respiratory depression or arrest
CNS: excess sedation, seizures to coma and arrest, pupillary constriction
GI: Nausea/vomiting

133
Q

morphine sulfate adult dose

A

2-4mg increments IVP until desired effect (max 10mg, or 20mg for burns)
can be given IM or IO

134
Q

morphine sulfate pediatric dose

A

.1mg/kg SIVP
may repeat up to 4mg max
can be given IM or IO