Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

[Mine] core curric - 2016 > Drug Nutrient Interactions > Flashcards

Drug Nutrient Interactions Flashcards

1
Q

Sulfasalazine (anti-inflammatory for UC or RA) inhibits

A

Folate metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Methotrexate inhibits

A

Folate metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

TNF-a Antibody (biologic therapy, IBD) interacts with

A

Protein metabolism

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Corticosteroids alter

A

Mineral metabolism

Protein metabolism (increased protein oxidation –> nitrogen losses)

Also can cause hyperglycemia and sodium retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Neomycin - used for HE or SIBO

A

Partial villous atrophy of gut and steatorrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Cholestyramine
(bile acid sequestrant)

A

Deficiency of fat soluble vitamins

Given too close to med dosing = no chance to breakdown and use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Orlistat (weight control medication)

A

Steatorrhea

Deficiency of fat soluble vitamins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Octreotide (anti-diarrheal)

A

Deficiency of fat soluble vitamins through fat malabsorption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Mineral oil (laxative)

A

Deficiency of fat soluble vitamins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Lomitapide (lipid-lowering agent)

A

Deficiency of fat soluble vitamins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Cyclosporine (immunosuppressant)

A

Hyperglycemia
Hyperkalemia
HLD
Hypomagnesemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Tacrolimus (immunosuppressant)

A

Alopecia
Hyperglycemia
Hyperkalemia
Hypomagnesemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Azathioprine (immunosuppressant)

A

Macrocytic anemia

Pancytopenia
- anemia (low RBC)
- leukopenia (low WBC)
- thrombocytopenia (low platelets)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What foods inhibit cytochrome P450 pathway and result in increased levels of:

cyclosporine
tacrolimus
sirolimus

A

Grapefruit
Pomegranate
Seville oranges
Star fruit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which 2 immunosuppressants are associated with new-onset DM after transplant?

A

Tacrolimus (greater prevalence)
Cyclosporine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which 3 immunosuppressants can induce hyperlipidemia?

A

Corticosteroids
Cyclosporine
Sirolimus

17
Q

Which med can reduce the effect of HLD when used as the primary immunosuppressant?

A

Tacrolimus

18
Q

Antibiotics decrease which nutrients?

A

Vit E
Vit K
Folate

19
Q

Glucocorticoids alter which nutrients?

A

Decreased -
Vitamin D
Phosphorous

Increased urinary loss
Calcium

20
Q

For patients with feedings tubes or dysphagia: should you crush the tablet Atripla?

(antiretroviral: efavirenz/emtricitabine/tenofovir DF)

A

Do not crush

21
Q

What should you check in all HIV-infected patients when providing nutrition care?

A

Triglycerides - especially prior to ILE

This is 2/2 diminished lipoprotein lipase expression in peripheral tissue –> reduced TG clearance –> hyperTG

22
Q

Major side effect of appetite stimulant megace (megestrol acetate)?

A

Hyperglycemia
Thrombosis
Adrenal insufficiency

23
Q

Major side effect of appetite stimulant marinol (dronabinol)?

A

Somnolence - especially in elderly

24
Q

Major side effect of growth hormones?

A

Edema
Insulin resistance
Fat atrophy

25
Q

What vit/mins can decrease the absorption of some antimicrobial agents?

  • azithromycin
  • levofloxacin
A

PO administered cations:
- Calcium
- Magnesium
- Aluminum

26
Q

Valproic acid can cause a deficiency in:

A

Carnitine

Valproic acid combines with carnitine leading to carnitine depletion

27
Q

Meds that increase urinary Vitamin C losses

A
  • Tetracycline (antibiotic)
  • Aspirin
  • Corticosteroids
28
Q

Which bronchodilator decreases serum thiamin?

A

Theophylline

29
Q

Which medication does water soluble Vitamin E increase the absorption of?

A

Cyclosporine (immunosuppressant)

30
Q

Long term corticosteroidsteroid use is associated with

A

Negative nitrogen balance
Net calcium loss
Glucose intolerance
Immunosuppression

31
Q

Recent ASPEN guidelines suggest omega 3 supplementation in cancer patients with progressive, unintentional weight loss benefit:

A

May help stabilize weight in patients on PO diets

32
Q

ceftriaxone compatibility with PN

A

Not compatible, forms precipitates with calcium

[Mine] core curric - 2016 (22 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions