Drug Monographs Flashcards
Acetaminophen: Brand Names
Albenol
Actimol
Atasol
Tylenol
Acetaminophen: Indications
Mild to moderate pain
Acetaminophen: Contradindications
Have you ever had a reaction to acetaminophen (Tylenol)?
Do you take it daily?
So you have any medical conditions with your liver?
HALL: Hypersensitivity, alcohol hepatitis with active consumption or liver dysfunction, liver injury, liver disease (acetaminophen induced)
- Hypersensitivity to Acetaminophen or any component of the formulation
- Acute liver injury
- Acetaminophen induced liver disease
- Severe alcoholic hepatitis or liver dysfunction with active alcohol consumption
Acetaminophen: Adult Dosage
- 500-1000mg PO (specifically, 15 mg/kg to a maximum of 1,000 mg) if over 145lbs get maximum
- Repeat: once after 4 hours
- 24-hour maximum: 3 g (3,000 mg) decrease to 1-2g if liver dysfunction
- May be used concurrently with ibuprofen for analgesia
Acetaminophen: Pediatric Dosage
Weight based dosing
PO Liquid (Infant): 80 mg/mL
- < 30 kg (66lbs): 15 mg/kg PO (use liquid preparation)
- 30-50 kg (66-110): 500 mg PO (may use liquid preparation or tablets, depending on patient ability)
- > 50 kg (110kg): 500-1,000 mg PO
May repeat once after 4 hours
24-hour maximum: 75 mg/kg or 1 g (1,000 mg)
Do not exceed 5 doses in 24-hours in patients < 12 years of age
Ibuprofen: Classification
Analgesic
Antipyretic
Nonsteroidal anti-inflammatory
Ibuprofen: Brand Names
Advil
Actiprofen
Motrin
Ibuprofen: Indication
Mild to moderate pain
Ibuprofen: Contraindications
Have you ever had a reaction to ibuprofen (Advil)
Are you pregnant?
Do you have an ulcer or GI bleed?
PHAB: Pregnancy, hypersensitivity, active internal bleeding
- Hypersensitivity to ibuprofen or other nonsteroidal anti-inflammatory drugs
- Active GI hemorrhage or ulcers
- Pregnancy (first, second, or third trimesters)
Ibuprofen: Adult Dosing
300-400 mg PO
May repeat: Every 4-6 hours
Maximum daily dose: 1,200 mg/day
Ibuprofen: Pediatric Dosing
No EMR
Salbutamol: Indications
Bronchospasm
Salbutamol: Contraindications
Known hypersensitivity to salbutamol
Salbutamol: Adult Dosing
5 mg nebulized; repeat doses back to back as necessary
4 x 100 mcg via metered dose inhaler with spacer; repeat as required
Salbutamol: Pediatric Dosing
Via nebulizer
- < 1 year: 2.5 mg
- ≥ 1 year: 5 mg
Via metered dose inhaler
- < 10 kg: not indicated
- 10-20 kg: 5 x 100 mcg per course; may repeat up to 3 times
- > 20 kg: 10 x 100 mcg per course; may repeat up to 3 times
Methoxyflurane: Brand Name
Penthrox
Methoxyflurane (Penthrox): Indications
Self-administered relief from moderate to severe pain in conscious, hemodynamically stable patients
Methoxyflurane (Penthrox): Contraindications
- Patients < 18 years of age
- Pregnancy, intended pregnancy, or current breast-feeding
- Inadequate patient understanding or lack of cooperation
- Decreased level of consciousness or head injury
- History of clinically significant renal impairment, e.g., reduced renal output
- History of liver dysfunction following previous exposure to halogenated anesthetics
- Current use of tetracycline antibiotics
- Personal or genetic history of malignant hyperthermia
- Muscular dystrophy
Methoxyflurane Mnemonic
CHECK A MAP
- Cardiac instability or respiratory depression (hemodynamic stability)
- Hypersensitivity (liver dysfunction from previous exposure)
- Established diagnosis of malignant hyperthermia
- Consciousness (i.e., altered level of consciousness, cooperating, understanding, injury)
- Kidneys – signs of kidney failure or renal impairment
- Age (Patient under 18)
- Muscular dystrophy
-Antibiotic (Current use of tetracycline antibiotics) - Pregnancy, trying or breastfeeding
Methoxyflurane (Penthrox): Adult dosage
3 mL self-administered via inhaler; may repeat after 20 minutes; maximum total volume 6 mL