Drug Monographs Flashcards

1
Q

Acetaminophen: Brand Names

A

Albenol
Actimol
Atasol
Tylenol

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2
Q

Acetaminophen: Indications

A

Mild to moderate pain

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3
Q

Acetaminophen: Contradindications

A

Have you ever had a reaction to acetaminophen (Tylenol)?
Do you take it daily?
So you have any medical conditions with your liver?

HALL: Hypersensitivity, alcohol hepatitis with active consumption or liver dysfunction, liver injury, liver disease (acetaminophen induced)

  • Hypersensitivity to Acetaminophen or any component of the formulation
  • Acute liver injury
  • Acetaminophen induced liver disease
  • Severe alcoholic hepatitis or liver dysfunction with active alcohol consumption
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4
Q

Acetaminophen: Adult Dosage

A
  • 500-1000mg PO (specifically, 15 mg/kg to a maximum of 1,000 mg) if over 145lbs get maximum
  • Repeat: once after 4 hours
  • 24-hour maximum: 3 g (3,000 mg) decrease to 1-2g if liver dysfunction
  • May be used concurrently with ibuprofen for analgesia
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5
Q

Acetaminophen: Pediatric Dosage

A

Weight based dosing
PO Liquid (Infant): 80 mg/mL

  • < 30 kg (66lbs): 15 mg/kg PO (use liquid preparation)
  • 30-50 kg (66-110): 500 mg PO (may use liquid preparation or tablets, depending on patient ability)
  • > 50 kg (110kg): 500-1,000 mg PO
    May repeat once after 4 hours
    24-hour maximum: 75 mg/kg or 1 g (1,000 mg)
    Do not exceed 5 doses in 24-hours in patients < 12 years of age
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6
Q

Ibuprofen: Classification

A

Analgesic

Antipyretic

Nonsteroidal anti-inflammatory

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7
Q

Ibuprofen: Brand Names

A

Advil
Actiprofen
Motrin

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8
Q

Ibuprofen: Indication

A

Mild to moderate pain

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9
Q

Ibuprofen: Contraindications

A

Have you ever had a reaction to ibuprofen (Advil)
Are you pregnant?
Do you have an ulcer or GI bleed?

PHAB: Pregnancy, hypersensitivity, active internal bleeding

  • Hypersensitivity to ibuprofen or other nonsteroidal anti-inflammatory drugs
  • Active GI hemorrhage or ulcers
  • Pregnancy (first, second, or third trimesters)
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10
Q

Ibuprofen: Adult Dosing

A

300-400 mg PO

May repeat: Every 4-6 hours

Maximum daily dose: 1,200 mg/day

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11
Q

Ibuprofen: Pediatric Dosing

A

No EMR

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12
Q

Salbutamol: Indications

A

Bronchospasm

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13
Q

Salbutamol: Contraindications

A

Known hypersensitivity to salbutamol

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14
Q

Salbutamol: Adult Dosing

A

5 mg nebulized; repeat doses back to back as necessary

4 x 100 mcg via metered dose inhaler with spacer; repeat as required

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15
Q

Salbutamol: Pediatric Dosing

A

Via nebulizer
- < 1 year: 2.5 mg
- ≥ 1 year: 5 mg

Via metered dose inhaler
- < 10 kg: not indicated
- 10-20 kg: 5 x 100 mcg per course; may repeat up to 3 times
- > 20 kg: 10 x 100 mcg per course; may repeat up to 3 times

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16
Q

Methoxyflurane: Brand Name

A

Penthrox

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17
Q

Methoxyflurane (Penthrox): Indications

A

Self-administered relief from moderate to severe pain in conscious, hemodynamically stable patients

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18
Q

Methoxyflurane (Penthrox): Contraindications

A
  • Patients < 18 years of age
  • Pregnancy, intended pregnancy, or current breast-feeding
  • Inadequate patient understanding or lack of cooperation
  • Decreased level of consciousness or head injury
  • History of clinically significant renal impairment, e.g., reduced renal output
  • History of liver dysfunction following previous exposure to halogenated anesthetics
  • Current use of tetracycline antibiotics
  • Personal or genetic history of malignant hyperthermia
  • Muscular dystrophy
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19
Q

Methoxyflurane Mnemonic

A

CHECK A MAP

  • Cardiac instability or respiratory depression (hemodynamic stability)
  • Hypersensitivity (liver dysfunction from previous exposure)
  • Established diagnosis of malignant hyperthermia
  • Consciousness (i.e., altered level of consciousness, cooperating, understanding, injury)
  • Kidneys – signs of kidney failure or renal impairment
  • Age (Patient under 18)
  • Muscular dystrophy
    -Antibiotic (Current use of tetracycline antibiotics)
  • Pregnancy, trying or breastfeeding
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20
Q

Methoxyflurane (Penthrox): Adult dosage

A

3 mL self-administered via inhaler; may repeat after 20 minutes; maximum total volume 6 mL

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21
Q

Glucagon: Indications

A

Confirmed hypoglycemia where patient mentation is unable to safely support administration of oral glucose

22
Q

Glucagon: Contraindications

A
  • Intranasal glucagon is contraindicated in patients under 4 years of age
  • Hypersensitivity
  • Pheochromocytoma (tumour on adrenal gland)
  • Insulinoma (tumour in pancreas)
23
Q

Glucagon: Adult dosage

A
  • 3 mg IN or 1 mg IM (choice will depend upon availability of product pending changeover)
  • If no clinical response within 15 minutes is seen following the first dose, consider administration of second 3 mg intranasal dose. CliniCall consultation is required prior to administration of second dose.
24
Q

Glucagon: Pediatric dosage

A

Same as adults

25
Q

Epinephrine: Indications

A

Anaphylaxis

26
Q

Epinephrine: Contraindications

A

There are no absolute contraindications to EPINEPHrine use in life-threatening situations such as anaphylaxis

27
Q

Epinephrine: Adult dosage

A

0.5 mg IM every 5 minutes

Repeat up to 3 times

28
Q

Epinephrine: Pediatric dosage

A

0.01 mg/kg IM to a maximum of 0.5 mg (0.5mg at 50kg or 110lbs)

Repeat up to 3 times

29
Q

Glucose: Indications

A

Known or suspected hypoglycemia in a conscious patient where there is no risk of aspiration or choking

30
Q

Glucose: Contraindications

A

None

31
Q

Glucose: Adult Dosage

A

15 g glucose PO (equivalent to one 38 g tube or 32 ml pouch)

Repeat at 5 minutes as necessary; no limit

32
Q

Glucose: Pediatric Dosage

A

15 g glucose, pediatrics may require a smaller dose depending on age

Repeat at 5 minutes if necessary

30 g glucose max

33
Q

Naloxone: Indications

A

Reversal of respiratory depression caused by suspected narcotic intoxication

34
Q

Naloxone: Contraindications

A

Allergy or known hypersensitivity to naloxone

Neonates

35
Q

Naloxone: Adult dosage

A

Naloxone IM every 3 minutes as required

First dose: 0.4 mg IM
Second dose: 0.4 mg IM if required
Third dose: 0.8 mg IM if required
Fourth dose: 2 mg IM if required

Maximum 4 doses: CliniCall consultation required prior to administration of further doses

36
Q

Naloxone: Pediatric dosage

A

0.1 mg/kg to maximum of 2 mg per dose (2mg dose at 20 kg or 44 lbs)

Repeat every 3 minutes

Maximum 4 doses

Higher dose for pediatric patients as they are unlikely to experience withdrawal

37
Q

Nitroglycerin: Indications

A

Relief from chest pain suggestive of acute coronary syndrome

38
Q

Nitroglycerin: Contraindications

A

BAE (Blood pressure, allergy, erectile dysfunction)

Known allergy or hypersensitivity to nitroglycerin
Use of Viagra (sildenafil) or Levitra (vardenafil) within the previous 24 hours
Use of Cialis (tadalafil) within the previous 48 hours
Severe anemia
Restrictive pericarditis or pericardial tamponade
Documented right sided acute myocardial infarction
Hypotension or uncorrected hypovolemia
Systolic blood pressure < 110 mmHg
Heart Rate <50 or >150

39
Q

Nitroglycerin: Adult dosage

A

0.4 mg SL every 3-5 minutes

Verify systolic blood pressure prior to administering each dose; systolic blood pressure must be ≥ 110 mmHg and heart rate must be between 50 and 150 beats/minute

40
Q

Nitroglycerin: Pediatric dosage

A

Not authorized for use in pediatrics

41
Q

Nitrous Oxide (Entonox): Indications

A

Self-administered relief from moderate to severe pain

42
Q

Nitrous Oxide (Entonox): Contraindications

A

mnemonic CDCPAIN:

Ability to Comply
Decompression sickness
Altered level of Consciousness
Pneumothorax
Air embolism
Inhalation injury
Nitroglycerin use within five minutes

43
Q

Nitrous Oxide (Entonox): Adult dosage

A

Self-administered to effect

44
Q

Nitrous Oxide (Entonox): Pediatric dosage

A

Self-administered to effect

45
Q

Acetylsalicylic Acid: Brand Names

A

Aspirin

46
Q

Acetylsalicylic Acid: Indications

A

Chest pain or signs and symptoms consistent with cardiac ischemia

47
Q

Acetylsalicylic Acid: Contraindication

A

BAAP (Bleeding, asthma, allergy, Pediatric)

Hypersensitivity to ASA or drug components
Patients who have experienced bronchospasm or other respiratory reaction precipitated by ASA or nonsteroidal anti-inflammatory drugs
Active or recent bleeding of any kind, including head injury or peptic ulcer disease
Pediatric patients with signs and symptoms consistent with viral illnesses (due to Reye’s Syndrome)

48
Q

Acetylsalicylic Acid: Contraindication

A

BAAP (Bleeding, asthma, allergy, Pediatric)

Hypersensitivity to ASA or drug components
Patients who have experienced bronchospasm or other respiratory reaction precipitated by ASA or nonsteroidal anti-inflammatory drugs
Active or recent bleeding of any kind, including head injury or peptic ulcer disease
Pediatric patients with signs and symptoms consistent with viral illnesses (due to Reye’s Syndrome)

49
Q

Acetylsalicylic Acid: Adult dosage

A

162 mg PO chewed and swallowed

50
Q

Acetylsalicylic Acid: Pediatric dosage

A

CliniCall consultation required prior to pediatric administration.

Chest pain in children is unlikely to be the result of ischemia; ASA is therefore not indicated unless there are rare, specific histories of disease.