Drug MOA Flashcards by Mikinna Garzella

Q

Calcium Carbonate (TUMS)

A

neutralize gastric acid and increases gastric pH

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Q

Magnium hydroxide (Milk of Magnesia)

A

neutralize gastric acid and increases gastric pH (GERD)

Osmotic with ions that draws fluid into stool to induce peristalsis (Constipation)

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Q

Mylanta Supreme

A

neutralize gastric acid and increases gastric pH

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Q

Famotidine (Pepcid)

A

reversibly binds inhibits H2 receptors to decrease gastric acid secretions

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Q

Ranitidine

A

reversibly binds inhibits H2 receptors to decrease gastric acid secretions

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Q

Cimetidine

A

reversibly binds inhibits H2 receptors to decrease gastric acid secretions

Remember: gynecomastia and impotence

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Q

Esomeprazole (Nexium)

A

irreversibly binds to H+/K+ ATPase on parietal cells to block gastric acid secretion

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Q

Lansoprazole (Prevacid)

A

irreversibly binds to H+/K+ ATPase on parietal cells to block gastric acid secretion

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Q

Omeprazole (Prilosec)

A

irreversibly binds to H+/K+ ATPase on parietal cells to block gastric acid secretion

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Q

Pantoprazole (Protonix)

A

irreversibly binds to H+/K+ ATPase on parietal cells to block gastric acid secretion

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Q

Dexlansoprazole (Dexilant)

A

irreversibly binds to H+/K+ ATPase on parietal cells to block gastric acid secretion

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Q

Metoclopramide (Reglan)

A

Dopamine antagonist that blcks serotonin receptors to decrease nausea and vomiting. Enhances response of ACh in upper GI tract to accelerate gastric emptying and increase LES tone/pressure

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Q

Misoprostol

A

prostaglandin E1 analog that mimics PG to have gastro-protectice abilities

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Q

Sucralfate (Carafate)

A

a sucrose-sulfate-aluminum complex that forms a protective barrier around the open ulcer

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Q

Psyllium (Metamucil)

A

Bulk forming anti-constipation drug that absorbs water to add bulk into the stool to increase peristalsis

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Q

Calcium polycarbophil (FiberCon)

A

Bulk forming anti-constipation drug that absorbs water to add bulk into the stool to increase peristalsis

Q

Glycerin

A

Osmotic with ions that draws fluid into stool to induce peristalsis (Constipation)

Q

Lactulose

A

Osmotic with ions that draws fluid into stool to induce peristalsis (Constipation)

Q

Miralax (PEG)

A

Osmotic with ions that draws fluid into stool to induce peristalsis (Constipation)

Q

Senna

A

Stimulant of neurons in the GI tract

Q

Bisacodyl (Dulcolax)

A

Stimulant of neurons in the GI tract

Q

Docusate sodium (colace)

A

Stool softeners that reduce the surface tension between the oil and water to soften the stool

Q

Lubiprostone (Amitiza)

A

Chloride Channel Activator to increase fluid in the GI

Indication: CIC, IBS-C, OIC

Q

Linaclotide (Linzess)

A

Guanylate Cyclase C Agonist to increase Chloride and Bicarb secretion into the lumen of the GI to increase the transit

Indication: CIC, IBS-C