Drug metabolism and toxicology Flashcards
1
Q
What is Drug metabolism
A
Term to describe the biotransformation of substances in the body so that they are eliminated more easily, via conversion of the drug into more water soluble compound by increasing its polarity.
2
Q
How are drugs metabolized through various reactions?
A
Oxidation = +/- of O2
Reduction= - H2
Hydrolysis = + H20
Conjugation = + of ionised group/lipid to drug e.g. acetyl
Condensation = 2 + drug molecules combine to form a molecular compound
Isomerisation = reaction changes to the drug molecule to optical isomer, either same or different
3
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4
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