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LCRS Tutorial flashcards > Drug Metabolism > Flashcards

Drug Metabolism Flashcards

1
Q

What is the major site of metabolism of foreign chemicals/xenobiotics in man?

A

liver

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2
Q

Where is cyP450 found?

A

smooth ER

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3
Q

What is the principle role of cyP450 and what does it require?

A

oxidation

requires oxygen + NADH

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4
Q

Give two examples of phase 1 metabolism

A

N-demthylation

Alcohol oxidation

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5
Q

Give two examples of phase 2 metabolism

A

sulphation

conjugation with glutathione

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6
Q

What are the features of glutathione?

A

tripeptide –> glutamic acid, glycine, cysteine
most abundant in liver
reacts with electrophilic chemical intermediates

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7
Q

unfinished

A

unfinished

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LCRS Tutorial flashcards (8 decks)

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