DRUG MATCHING

Question 1

Inhibition of cell wall synthesis – competitive inhibitor - binds to enzyme that forms protein cross-linkages; wall is weakened and cell lyses

Answer 1

Penicillin G and V

Amoxicillin

Piperacillin

Ampicillin

Methicillin

Oxacillin

Question 2

Inhibition of cell wall synthesis – inhibits addition of new peptidoglycan molecules in growing cell wall; wall is weakened and cell lyses

Answer 2

Bacitracin

Question 3

Inhibition of cell wall synthesis – binds to peptides in peptidoglycanto prevent protein cross linking; wall is weakened and cell lyses

Answer 3

Vancomycin

Question 4

Inhibition of cell wall synthesis – binds to lipids in G(+) cell wall; wall is weakened and cell lyses

Answer 4

Teixobactin

Question 5

Disruption

of plasma membrane function; membrane becomes leaky and the cell dies

Answer 5

Polymyxin B

Polymyxin E

Question 6

Inhibition of DNA replication (targets helicase - DNA unwinding enzyme)

Answer 6

Quinolones

Question 7

Inhibition of DNA replication (drug gets incorporated into DNA and it makes the DNA unstable)

Answer 7

Metronidazole

Question 8

Inhibition of
protein synthesis (transcription)
targets RNA polymerase so mRNA doesn’t get made

Answer 8

Rifampin

Question 9

Inhibition of protein synthesis (translation) targets ribosomes so proteins don’t get made

Answer 9

Clindamycin
Doxycycline
Sumycin

Clarithromycin
Azithromycin
Erythromycin

Gentamycin sulfate
Tobramycin
Streptomycin
Neomycin

Chloramphenicol
Tetracycline

Question 10

Competitive Inhibition – mimics PABA and binds to enzyme active site to block PABA and to block folic acid synthesis

Answer 10

Sulfonamides (Bactrim, Septra)