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Pharmacology Test II > Drug List Pharm II - Sheet 1 > Flashcards

Drug List Pharm II - Sheet 1 Flashcards

1
Q

Donepezil

A

Central AChE inhibitor/Tx mild-moderate Alzheimer/Mentioned: cause diarrhea nausea vomiting cramps anorexia and vivid dreams

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2
Q

Rivastigmine

A

Central AChE inhibitor/Tx mild-moderate Alzheimer/Mentioned: cause diarrhea nausea vomiting cramps anorexia and vivid dreams

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3
Q

Galantamine

A

Central AChE inhibitor/Tx mild-moderate Alzheimer/Mentioned: cause diarrhea nausea vomiting cramps anorexia and vivid dreams. Risk of causing acute heart failure

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4
Q

Neostigmine

A

reversible AChE inhibitor/Tx MG. Nicotinic antagonist paralytic antidote. Glaucoma. Urinary retention/Mentioned: be effective in treating paralytic ileus but limited use due to side effects

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5
Q

Pyridostigmine

A

reversible AChE inhibitor/Tx MG. Ogilvie syndrome/Mentioned: a primary Tx for pseudoobstruction of the GI (ogilvie). Long T1/2

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6
Q

Malathion

A

irreversible AChE inhibitor/Tx lice/Mentioned: an organophosphate poison that can be treated with atropine

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7
Q

Parathion

A

irreversible AChE inhibitor/Used as insecticide/Mentioned: an organophosphate poison that can be treated with atropine

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8
Q

Soman. Sarin. Tabun. VX

A

irreversible AChE inhibitor/Used nerve agent/Mentioned: an poison that can be treated with atropine

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9
Q

Ecothiophate

A

irreversible AChE inhibitor/Tx chronic glaucoma/Mentioned: a slow acting antagonist so it does not act as a nerve agent instead

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10
Q

Diisopropyl fluorophosphate

A

irreversible AChE inhibitor/Tx chronic glaucoma/used as both medically and as a chemical agent

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11
Q

Edrophonium

A

reversible AChE inhibitor/Dx MG vs cholinergic crisis vs LEMS/Mentioned: a part of the tensilon test

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12
Q

Ambenonium

A

reversible AChE inhibitor/Tx MG/Mentioned: a minor drug

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13
Q

Physostigmine

A

reversible AChE inhibitor/Tx MG. Glaucoma. Alzheimers/Mentioned: antidote to anticholinergic paralysis from anesthesia ie. Vecuronium a nicotinic rec. antagonist

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14
Q

Methacholine

A

non selective mAChR agonist/Dx allergic asthma/Mentioned: part of methacholine challenge test and contraindicated in MI. CVA. HTN

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15
Q

Carbachol

A

cholinergic agonist/Tx glaucoma/Mentioned: a minor drug

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16
Q

Bethanechol

A

mAChR agonist/Tx Urinary retention/Mentioned: not affecting nicotinic receptors unlike carbachol

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17
Q

Cevimeline

A

mAChR agonist/Tx Xerostomia/mentioned for treating xerostomia due to Sjorgens syndrome

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18
Q

Pilocarpine

A

mAChR agonist/Tx glaucoma. Xerostomia/mentioned for treating xerostomia due to Sjorgens syndrome

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19
Q

Trihexyphenidyl

A

mAChR inhibitor/Tx Parkinson’s disease/Mentioned: reduce cholinergic tone in the CNS

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20
Q

Benztropine

A

mAChR inhibitor/Tx Parkinson’s disease and hyperhydrosis/Mentioned: reduce cholinergic tone in the CNS

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21
Q

Atropine

A

mAChR inhibitor/Tx Mushroom poisoning. Anti AChase OD. Nerve gas attack/mentioned for use in dilation for eye exams. Sinus bradycardia. Asthma beta 2 agonist alternative. Do not use in narrow angle glaucoma

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22
Q

Scopolamine

A

mAChR inhibitor/Tx nausea. Vomiting. Vertigo/Mentioned: use in eye exams and may cause psychosis

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23
Q

Methscopolamine

A

mAChR inhibitor/Tx Peptic Ulcers/Mentioned: have arrhythmias. constipation and urinary retention as side effects

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24
Q

Hyoscyamine

A

mAChR inhibitor/Tx IBS. GI upset/Mentioned: use in eye exams

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25
Q

Ipratropium

A

mAChR inhibitor/Tx COPD/Mentioned: be more effective than beta agonists in treating COPD

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26
Q

Tiotropium

A

mAChR inhibitor/Tx COPD/Mentioned: very effective Tx for COPD due to long half life

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27
Q

Oxybutynin

A

mAChR inhibitor/Tx Hyperhydrosis. Overactive bladder/Mentioned: also cause constipation and urinary retention

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28
Q

Glycopyrrolate

A

mAChR inhibitor/Tx hyperhydrosis. Bradycardia. peptic ulcers/Mentioned: also cause constipation and urinary retention

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29
Q

Propantheline

A

mAChR inhibitor/Tx hyperhydrosis. Overactive bladder/Mentioned: have side effects of constipation and urinary retention

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30
Q

Terodiline

A

AChR inhibitor/Tx overactive bladder/Mentioned: a minor drug

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31
Q

Succinylcholine

A

nACh agonist/Tx short term muscle relaxant in endotrach intubation/Mentioned: contraindicated with pseudocholinesterases (butyrylcholinesterase) as it breaks succinylcholine very quickly

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32
Q

Pancuronium

A

competitive nAChR inhibitor/Use as paralytic in surgery/Mentioned: work as nicotinic receptor antagonist and is long acting

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33
Q

Tubocurarine

A

nAChR inhibitor/Use as paralytic in surgery/Mentioned: long acting

34
Q

Vecuronium

A

competitive nAChR inhibitor/Use as paralytic in surgery/Mentioned: work as nicotinic receptor antagonist and is intermediate acting

35
Q

Rocuronium

A

competitive nAChR inhibitor/Use as paralytic in surgery/Mentioned: work as nicotinic receptor antagonist and is intermediate acting

36
Q

Mivacurium

A

competitive ganglionic nAChR inhibitor/Tx hypertension with aortic dissection/Mentioned: work as nicotinic receptor antagonist and is short acting. Minor drug

37
Q

Trimethaphan

A

competitive ganglionic nAChR inhibitor/Tx hypertension with aortic dissection/Mentioned: cause paralytic ileus. orthostatic hypotension and respiratory arrest as side effects

38
Q

Mecamylamine

A

noncompetitive ganglionic nAChR inhibitor/Tx hypertension/Mentioned: cause paralytic ileus. orthostatic hypotension and respiratory arrest as side effects. Minor drug

39
Q

Quinine

A

antimalarial/Tx malaria/Mentioned: a typo for quinidine which is a 1A antiarrhythmic which can cause the mentioned cardiac issues at low doses unlike quinine which requires very high doses

40
Q

Disopyramide

A

1A antiarrhythmic/Tx ventricular tachycardia/Mentioned: have a high risk of causing acute heart failure

41
Q

Procainamide

A

1A antiarrhythmic/Tx ventricular tachycardia/Mentioned: have a high

42
Q

Pirenzepine

A

mAChR inhibitor/Tx Peptic ulcers/Mentioned: the primary treatment for peptic ulcers

43
Q

Tetanus toxin

A

neurotoxin/causes truisms. Risus sardonicus. Opisthotonos/Mentioned: working by degrading the SNARE protein synaptobrevin and inhibiting release of neurotransmitters

44
Q

Botulinum toxin

A

neurotoxin/causes flaccid paralysis/Mentioned: Binds SNARE = stops vesicle to wall binding. Used for torticolis. Strabismus. Wrinkles. Hyperhydrosis

45
Q

Epinephrine

A

B2-agonist/Tx Cardiac Arrest. Anaphylaxis. Asthma/Mentioned: Prod by chromaffin. B«B2. incr inotrop. Chronotropy. decr TPVR. incr blood flow. dilate airways

46
Q

Hemicholinium-3

A

indirect AChR inhibitor/experimental due to lack of specificity/mentioned mechanism is blocking choline transport into neuron

47
Q

Norepinephrine

A

B-agonist/Tx ADHD. Depression. Hypotension/Mentioned: Prod by chromaffin. Alpha>Beta. incr TPVR. Incr. inotropy

48
Q

Vesamicol

A

physiological ACh Inhibitor/experimental due to lack of specificity/mentioned mechanism is blocking ACh uptake into vesicles

49
Q

Isoproterenol

A

non selective B-agonist/Highly selective for Beta»Alpha rec/Synthetic catecholamine/+ inotropic and chronotropic effects on heart/Tx bradycardia. heart block

50
Q

Dopamine

A

D1-agonist/Tx Parkinsons. Schizo/Mentioned: made by chromaffin. Binds B<D rec

51
Q

Midodrine

A

A1-agonist/Tx ortho HTN/Mentioned: Prodrug metabolite is a1 agonist

52
Q

Phenylephrine

A

A1-agonist/Tx nasal congestion/Mentioned: resistance to COMT

53
Q

Methyldopa

A

A2-agonist/Tx HTN in pregnancy/Mentioned: a2-Gi-decr cAMP path. Decr TPVR BP sympathetic

54
Q

Clonidine

A

A2-agonist/Tx HTN in pregnancy

55
Q

Tizanidine

A

A2-agonist/Tx migraines. Neuropathic pain/Mentioned: Muscle relaxant

56
Q

Dobutamine

A

B1-agonist/Tx Severe Heart Failure/Mentioned: Inotropic effects > chronotropic

57
Q

Metaproterenol Terbutaline Albuterol Formoterol Salmeterol

A

B2-agonist/Tx mostly asthma and COPD/Mentioned: significant bronchodilation

58
Q

Ephedrine

A

general adrenergic agonist/Tx refractory hypotension/Mentioned: coast guard cocktail

59
Q

Pseudoephedrine

A

general adrenergic agonist/Tx nasal congestion/Mentioned: Nasal decongestants

60
Q

Amphetamine. Methamphetamine. Methylphenidate

A

Psychostimulant/Tx ADHD/Mentioned: Reverses DAT = release NE Dopamine serotonin. appetite suppressant

61
Q

Atomoxetine

A

NE reuptake inhibitor/Tx ADD/Mentioned: SFx orthostatic tachycardia. hypertension

62
Q

Duloxetine

A

5HT-NE reuptake inhibitor(SNRI)/Tx depression/Mentioned: minor drug

63
Q

Cocaine

A

NE reuptake inhibitor/Mentioned: Major drug of abuse

64
Q

Fenoldopam

A

D1Partial agonist/Tx HTN Crisis/Mentioned: w/ full agonist = diuresis. Alone = stim AC.cAMP=relax smooth muscle

65
Q

Bromocriptine

A

D2»5HT agonist/Tx Parkinson’s. pituitary adenomas via incr. Prolactin/Mentioned: mimics dopamine. Dopamine inhibits prolactin

66
Q

Ropinirole

A

D2 agonist/Tx mild Parkinson’s/Mentioned: minor drug

67
Q

Pramipexole

A

D3 agonist/Tx advanced Parkinson’s/Mentioned: always give w/ levodopa. Neuroprotective

68
Q

Phentolamine

A

a1=a2 receptor blocker/Tx pheochromocytoma/Severe tachycardia via a2 block

69
Q

Prazosin

A

a1 antagonist/Tx hypertension/Mentioned: vasodilator. Very little tachycardia

70
Q

Terazosin

A

a1antagonist/Tx Hypertension. Benign Prostatic Hyperplasia symptoms/Mentioned: a1D induces apoptosis

71
Q

Doxazosin

A

a1antagonist/Tx Hypertension. BPH/Mentioned: a1D induces apoptosis

72
Q

Phenoxybenzamine

A

Irreversible a1 > a2 receptor blocker/Tx pheochromocytoma/Mentioned: Orthostatic hypotension due to decreased a2 block. tachycardia (< than phentolamine)

73
Q

Tamsulosin

A

a1A-a1D antagonist/Tx BPH/Mentioned:a1D induces apoptosis. Less ortho hypotension vs other Zosins

74
Q

Alfuzosin

A

a1 antagonist/Tx BPH/Mentioned: may prolong QT on EKG

75
Q

Labetalol

A

a1>B antagonist/Tx HTN Crisis. pre-eclampsia HTN/Mentioned: effects due to racemic mix. May cause hepatitis. Membrane stabilizing

76
Q

Chlorpromazine Haloperidol

A

D antagonist/Tx Psychosis. Schizo/Mentioned: a-antagonist = possible side effects

77
Q

Metoprolol Atenolol

A

B1-antagonist/Tx angina/Mentioned: Avoid in asthma. More effective than nonselective Rx. Membrane stabilizing

78
Q

Propranolol Nadolol Timolol

A

B1 = B2/Mentioned: Timolol Tx glaucoma(timolol. CVD. HTN. Angina

79
Q

Sotalol

A

B antagonist/Tx HTN/Mentioned: Also Class 3 anti-arrhythmic. prolongs phase 3 vent AP

80
Q

Pindolol

A

B1=B2/Tx HTN./ Mentioned: angina w/ less bradycardia w/ decr in HR

Pharmacology Test II (1 decks)

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