Drug list

Question 1

Whats a drug that small, non ionised and lipophilic

Answer 1

Theophylline

- 100% able to go to portal vein

Question 2

Whats a drug that larger, and ionised

Answer 2

Gentamicin: poorly able to cross the gut membrane - retained in the gut.

Question 3

What is a prodrug

Answer 3

Codeine: metabolised to active form (release) morphine

Question 4

What are the features of morphine

Answer 4

• rapidly metabolised in the liver - low oral bioavailability so needs bigger dosing
• however a conjugated form Morphine-6-glucuronide is more active