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Pharmacology > Drug List 4: Eicosanoids & Leukotrienes > Flashcards

Drug List 4: Eicosanoids & Leukotrienes Flashcards

0
Q

prostaglandin E1 (PGE1)

A

Class: endogenous eicosanoid
mech: EP R agonist
Indication: erectile dysfunction, maintain patent ductus arteriosus
effect: vasodilation, inhibit platelet aggregation
SE: apnea, bradycardia, hypotension, hypercapnia

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1
Q

prostaglandin D2 (PGD2)

A

class: Endogenous eicosanoid
mech: DP1 & DP2/CRTH2 R agonist
Ind: –
effect: vasodilation, plasma exudation, chemotaxis, inflammation, bronchoconstriction, sleep
SE: –

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2
Q

prostaglandin E2 (PGE2)

A

class: endogenous eicosanoid
mech: EP R agonist
Ind: facilitate labor/induce abortion, (*better than PG-F)
effects: inhibit ADH & natriuresis; vasodilate, inflammation
SE: fever, GI cramps, diarrhea

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3
Q 
prostaglandin I2 (PGI2)
* aka: prostacyclin
A

class: endogenous eicosanoid
mech: IP R agonist
Ind: primary pulm. HTN, heparin substitute
Effects: vasodilation, inhibit platelet aggregation
SE: flushing, headache, hypotension, nausea, diarrhea

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4
Q

prostaglandin F2a (PGf2a)

A

class: endogenous eicosanoid
mech: FP R agonist
Ind: facilitate labor/induce abortion (2nd choice drug)
Effects: non-vascular sm. muscle contraction (uterus), vasoconstriction
SE: bronchoconstriction, nausea, vomiting, diarrhea

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5
Q

carboprost

A

class: synthetic PGF analog
mech: FP R agonist (mimics PG-F, but longer lasting)
Ind: postpartum hemorrhage, induce abortion
Effects: oxytocic
SE: vomiting, diarrhea, bronchoconstriction

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6
Q

thromboxane A2 (TXA2)

A

class: endogenous eicosanoid
mech: TP R agonist
ind: – (not a Tx)
effects: vasoconstriction, bronchoconstriction, stimulate platelet aggregation

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7
Q

Leukotriene B (LTB4)

A

class: endogenous eicosanoid
mech: LT R agonist
Ind: — (not a Tx)
effects: chemotaxis & recruitment of inflammatory cells

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8
Q

cysteinyl leukotrienes (LTs C/D/E)

A

class: endogenous eicosanoid
mech: cysLT R agonist, activates PLC
Ind: – (not a Tx)
effects: bronchoconstriction, increase capillary permeability

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9
Q

iloprost

A

Class: synthetic prostaglandin
mech: mimcs PGI (IP R agonist)
Ind: pulmonary HTN
effects: vasodilation, inhibits platelet aggregation
SE: flushing, headache, hypotension, nausea, vomiting

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10
Q

misoprostol

A

class: synthetic prostaglandin
mech: mimics PGE2 (EP R agonist)
Ind: prevent ulcers, induce abortion
Effects: increase gastric cytoprotection, oxytocic
SE: fever, GI cramps, diarrhea

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11
Q

latanoprost

A 
class: synthetic prostaglandin
Mech: mimics PGF2a (FP R agonist)
Ind: ocular HTN, glaucoma
effects: reduce IOP
SE: pigmentation, irritation/inflammation, eyelash growth
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12
Q

bimatoprost

A 
class: synthetic prostaglandin
Mech: mimics PGF2a (FP R agonist)
Ind: ocular HTN, glaucoma
Effects: reduce IOP
SE: pigmentation, irritation/inflammation, eyelash growth
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13
Q

NSAIDs (Non-Steroidal Anti-Inflammatory Drugs)

A

class: NSAID
mech: inhibit COX
Ind: inflammation, pain, fever
Effects: decrease inflammation, pain, & fever
SE: may cause ulcers, fluid retention –> weight gain & arterial HTN, increase risk of CV thrombotic events

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14
Q

Aspirin (ASA)

A

class: PG synthesis inhibitor
mech: COX1/2 inhibitor
Ind: heart attack prophylaxis (only baby size), decrease risk thrombosis, reduce inflammation
Effects: decrease inflammation, decrease pain
SE: Reye’s syndrome, + others (like NSAIDs)

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15
Q

ibuprofen

A

Class: PG synthesis inhibitor
Mech: COX1/2 inhibitor
Ind: inflammation, fever, pain
Effects: decrease Sx (inflamm, pain, fever)
SE: ulcers, weight gain (H2O retention), arterial HTN, increased risk CV thrombotic events

16
Q

celecoxib

A 
Class: PG synthesis inhibitor ("Coxib")
mech: COX2 inhibitor, ~selective!
Ind: inflamm, pain, fever
Effects: decrease inflamm & pain
SE: allergic rxn if sensitive to sulfonamides, NSAID SEs
17
Q

acetominophen

A 
class: weak PG inhibitor
Mech: COX3 inhibitor (not useful for humans)
Ind: inflammation, fever/pain
Effects: decrease inflamm, pain, fever
SE: liver toxicity risk if EtOH abuse
18
Q

glucocorticoids

A

class: –
mech: steroid anti-inflamm. agent
Ind: inflammation (only)
effects: many.
SE: many.

19
Q

Zilueton

A

Class: leukotriene synthesis inhibitor, aka: anti-leutoktriene agent
mech: blocks 5-LOX
Ind: asthma prophylaxis
Effects: decrease bronchoconstriction (from asthma)
SE: possible liver toxicity

20
Q

zafirlukast

A

Class: leukotriene antagonist/anti-leukotriene agent
Mech: blocks CYSLT-1 R
Ind: asthma prophylaxis
Effects: decrease bronchocostriction (from asthma)
SE: –

21
Q

lubiprostone

A

class: synthetic prostaglandin analogue
Mech: CIC-2 (chloride channel agonist)
Ind: idiopathic constipation, IBS w/ constipation
Effects: increase chloride efflux & fluid secretion into GI lumen, soften stools
SE: nausea, diarrhea

Pharmacology (8 decks)

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