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Epilepsy > Drug interactions/PK > Flashcards

Drug interactions/PK Flashcards

1
Q

CBZ is metabolized by:

A

CYP 3A4

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2
Q

Brivaracetam is metabolized by:

A

CYP 2C19

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3
Q

Clobazam is metabolized by (3):

A

CYP 2C19, 3A4, and 2B6

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4
Q

Eslicarbazepine is metabolized by:

A

Hydrolysis (1st pass)

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5
Q

Ethosuximide is metabolized by:

A

CYP 3A4

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6
Q

Gabapentin is metabolized by:

A

None

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7
Q

Lamotrigine is metabolized by:

A

Glucuronidation in liver

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8
Q

Lacosamide is metabolized by:

A

CYP 2C19

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9
Q

Levetiracetam is metabolized by (2):

A

hydrolysis in liver (24%) but mostly renally eliminated (66%)

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10
Q

Oxcarbazepine (MHD, the active metabolite) is metabolized by (2):

A

CYP 3A4 and glucuronidation

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11
Q

Phenobarbital is metabolized by (3):

A

N-glucosidation and CYP 2C9/19

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12
Q

Phenytoin is metabolized by (2):

A

CYP 2C9/19

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13
Q

Perampanel is metabolized by (2):

A

CYP 3A4 and/or CYP 3A5

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14
Q

Pregabalin is metabolized by:

A

None

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15
Q

Primidone is metabolized by (2):

A

CYP 2C9/19

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16
Q

Rufinamide is metabolized by

A

Hydrolysis

17
Q

Topiramate metabolism:

A

unknown

18
Q

Valproate/valproic acid is metablized by (2):

A

Glucuronidation and beta-oxidation

19
Q

These 7 drugs need dose adjustment in impaired renal function - name them:

A

Eslicarbazepine, gabapentin, lacosamide, levetiracetam, oxcarbazepine, pregabalin, topiramate

20
Q

These 3 drugs are highly protein bound”

A

Carbazepine, valproate/valproic acid, phenytoin

21
Q

These 7 drugs do not induce any enzymes:

A

brivaracetam, ethosuximide, gabapentin, lacosamide, levetiracetam, pregabalin, valproate/valproic acid

22
Q

These 4 drugs induce CYP 1A2/2C/3A4, GLUC, epoxide hydrolase

A

CBZ, PB, PHT, PRM

23
Q

Clobazam weakly induces:

A

CYP 3A4

24
Q

Lamotrigine induces:

A

glucuronidation

25
Q

Oxcarbazepine weakly induce (2):

A

CYP 3A4, GLUC

26
Q

Perampanel weakly induce

A

CYP 2B6/3A4/GLUC

27
Q

Rufinamide weakly induce:

A

CYP 3A4

28
Q

Topiramate induce:

A

CYP 3A4

29
Q

Brivaracetam inhibits:

A

Epoxide hydrolase

30
Q

Clobazam inhibits:

A

CYP 2D6

31
Q

These 3 drugs inhibit CYP 2C19:

A

Eslicarbazepine, oxcarbazepine, topiramate

32
Q

Perampanel weakly inhibits (3):

A

CYP 2C8, 3A4, GLUC

33
Q

Rufinamide weakly inhibits:

A

CYP 2E1

34
Q

Valproate/valproic acid inhibits (4):

A

CYP 2C9, 3A, GLUC, EH

Epilepsy (3 decks)

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