Drug interactions/PK

Question 1

CBZ is metabolized by:

Answer 1

CYP 3A4

Question 2

Brivaracetam is metabolized by:

Answer 2

CYP 2C19

Question 3

Clobazam is metabolized by (3):

Answer 3

CYP 2C19, 3A4, and 2B6

Question 4

Eslicarbazepine is metabolized by:

Answer 4

Hydrolysis (1st pass)

Question 5

Ethosuximide is metabolized by:

Answer 5

CYP 3A4

Question 6

Gabapentin is metabolized by:

Answer 6

None

Question 7

Lamotrigine is metabolized by:

Answer 7

Glucuronidation in liver

Question 8

Lacosamide is metabolized by:

Answer 8

CYP 2C19

Question 9

Levetiracetam is metabolized by (2):

Answer 9

hydrolysis in liver (24%) but mostly renally eliminated (66%)

Question 10

Oxcarbazepine (MHD, the active metabolite) is metabolized by (2):

Answer 10

CYP 3A4 and glucuronidation

Question 11

Phenobarbital is metabolized by (3):

Answer 11

N-glucosidation and CYP 2C9/19

Question 12

Phenytoin is metabolized by (2):

Answer 12

CYP 2C9/19

Question 13

Perampanel is metabolized by (2):

Answer 13

CYP 3A4 and/or CYP 3A5

Question 14

Pregabalin is metabolized by:

Answer 14

None

Question 15

Primidone is metabolized by (2):

Answer 15

CYP 2C9/19

Question 16

Rufinamide is metabolized by

Answer 16

Hydrolysis

Question 17

Topiramate metabolism:

Answer 17

unknown

Question 18

Valproate/valproic acid is metablized by (2):

Answer 18

Glucuronidation and beta-oxidation

Question 19

These 7 drugs need dose adjustment in impaired renal function - name them:

Answer 19

Eslicarbazepine, gabapentin, lacosamide, levetiracetam, oxcarbazepine, pregabalin, topiramate

Question 20

These 3 drugs are highly protein bound”

Answer 20

Carbazepine, valproate/valproic acid, phenytoin

Question 21

These 7 drugs do not induce any enzymes:

Answer 21

brivaracetam, ethosuximide, gabapentin, lacosamide, levetiracetam, pregabalin, valproate/valproic acid

Question 22

These 4 drugs induce CYP 1A2/2C/3A4, GLUC, epoxide hydrolase

Answer 22

CBZ, PB, PHT, PRM

Question 23

Clobazam weakly induces:

Answer 23

CYP 3A4

Question 24

Lamotrigine induces:

Answer 24

glucuronidation

Question 25

Oxcarbazepine weakly induce (2):

Answer 25

CYP 3A4, GLUC

Question 26

Perampanel weakly induce

Answer 26

CYP 2B6/3A4/GLUC

Question 27

Rufinamide weakly induce:

Answer 27

CYP 3A4

Question 28

Topiramate induce:

Answer 28

CYP 3A4

Question 29

Brivaracetam inhibits:

Answer 29

Epoxide hydrolase

Question 30

Clobazam inhibits:

Answer 30

CYP 2D6

Question 31

These 3 drugs inhibit CYP 2C19:

Answer 31

Eslicarbazepine, oxcarbazepine, topiramate

Question 32

Perampanel weakly inhibits (3):

Answer 32

CYP 2C8, 3A4, GLUC

Question 33

Rufinamide weakly inhibits:

Answer 33

CYP 2E1

Question 34

Valproate/valproic acid inhibits (4):

Answer 34

CYP 2C9, 3A, GLUC, EH