Drug Interactions

Question 1

The most common drug interactions involving sedative-hypnotics are interactions with **other central nervous system depressant **drugs, leading to additive effects.

These interactions have some
therapeutic usefulness when these drugs are used as _______________.

Answer 1

adjuvants in anesthesia practice

Question 2

However, if not anticipated, such interactions
can lead to serious consequences, including enhanced depression
with concomitant use of many other drugs.

Additive effects can be
predicted with concomitant use of ______________.

Answer 2

• alcoholic beverages,
• opioid analgesics,
• anticonvulsants,
• and phenothiazines

Question 3

Less obvious but
just as important is enhanced central nervous system depression
with a variety of__________________

Answer 3

• antihistamines,
• antihypertensive agents, and
• antidepressant drugs of the tricyclic class.

Question 4

Interactions involving changes in the activity of hepatic
drug-metabolizing enzyme systems have been discussed
(see also Chapters 4 and 66).