DRUG INTERACTIONS Flashcards
INCOMPATIBILITY
chemical deterioration of the two drugs when mixed together forms a precipitate, haziness, or change in color
Drug Interactions
the effect of one drug on another drug includes otc drugs and herbal drugs
- Pharmocokinetic interactions
- Pharmocodynamic Interactions
Pharmocokinetic Interactions
interactions involving what the body does to the drug
absorption, distribution, metabolism, and excretion
Absorption
changing absorption of another drug by
- changing GI motility
- changing gastric pH
- forming drug complexes
- affecting bacteria
Distribution
drugs compete with each other for the protein binding sites
Metabolism
drugs can act induce or inhibit the action of liver enzymes of other drugs
P-450
a group of enzymes located in the liver that transforms drug
Enzyme Inducer
a drug that causes the liver to synthesize more P-450
Enzyme Inhibitors
a drug that decreases the number of liver enzymes or prevents them from working properly
Excretion
Drugs that decrease heart rate, decrease blood flow, decrease excretion and increase drug level
Pharmocodynamic Interactions
interactions involving what the drug does to the body
Additive Interactions
effect is the sum of both drugs effects
Synergistic Interactions
effect is greater than the sum of the drug effects may be advantageous
and may cause too much affect
Antagonistic Interactions
effect is less than if the drugs were given separately may be harmful
or may be advantageous
Minimize drug-drug interactions
taking a thorough drug history
advising patient to avoid otc meds
monitoring for known drug interactions that can occur
being alert for as yet unknown reactions
