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Pharm 225 > Drug Interactions > Flashcards

Drug Interactions Flashcards

1
Q

What are the three types of drug interactions?

A

Drug-Medical condition interaction
Drug-food interaction
Drug-drug interaction

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2
Q

What food interacts with CYP 3A4 and what is the specific compound?

A

Grapefruit-bergamotten

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3
Q

What is a victim drug and perpetrator drug?

A

victim= what is effected
Perpetrator= new drug that effects another

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4
Q

What is the interaction of naloxone and opiods?

A

Antagonistic

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5
Q

What is a pharmacodynamic interaction? What is a pharmacokinetic interaction?

A

Dynamic= affects safety or efficacy- additive, synergistic, antagonistic
Kinetic= effect ADME

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6
Q

What are the 3 most common Pharmacokinetic interactions?

A

GIT,Distribution, elimination

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7
Q

What is altered in absorption interaction?

A

Rate= Ka and Tmax= onset
Extent= F and Cmax= intesity and duration

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8
Q

What is altered in distribution?

A

f ub

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9
Q

What enzyme is mostly used in metabolism?

A

CYP 3A and 2C

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10
Q

What are efflux transporters? What are influx?

A

E= ABC= ATP
I=SLC

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11
Q

Which enzymes have interpatient variability?

A

CYP 2D6 and 2C

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12
Q

What does apical side mean? Basolateral?

A

Apical= Gut
Basolateral= body

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13
Q

What is the most common form of enzyme inhibition?

A

Reversible competitive= they compete for site

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14
Q

What is non-competitive?

A

bind to different sites= alters the activity

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15
Q

WHat is irreversible inhibition?

A

covalently bonded

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16
Q

When do you see enzyme activity return for reversible and irreversible inhibition?

A

R= when inhibitor [] dies off
I= synthesize new

17
Q

How can enzymes be induced?

A

More transcription= more synthesis of enzyme
a protein stabilizer for enzyme

18
Q

What are common enzyme inducers?

A

CBM
Phentyoin, Barbituates
Alcohol, Smoke

19
Q

What is the duality of effect of a molecule?

A

Can both inhibit one and induce a different molecule

20
Q
A

Pharm 225 (3 decks)

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