Drug Interaction Flashcards

1
Q

Drug interaction is the interplay between two or more drugs which alters the ________ _____________ of one or more drugs and may increase or decrease the _________ or ________ _______ of the drugs.

A

Plasma concentration

Efficacy or adverse effects

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2
Q

What are the 2 main types of drug interaction

A

Pharmacokinetic DI
Pharmacodynamic DI

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3
Q

Pharmacokinetic DI:occurs when one ormore drug alters the __________, __________, ___________ or _____________ of another drug such that its plasma concentration is altered

A

absorption, distribution, metabolism or excretion

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4
Q

PharmacodynamicD:I occurs when one or more drugs alters the __________ or ________ effects of another

A

Pharmacological or toxic

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5
Q

In the alteration of absorption
- Calcium containing drugs (Antacids) vs tetracycline

A

Calcium chelates tetracycline (antibiotic) to form a complex and prevent its absorption thereby reducing its plasma conc

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6
Q

In the alteration of metabolism
- Efavirenz vs artemether/lumefantrine

A

efavirenz (anti retroviral drug) inhibits cytochrome P3A4 enzyme which metabolises the antimalarial drug thereby reducing their plasma conc

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7
Q

In Additive toxicity
- Concomitant use of NSAIDs and glucocorticoids

A

increases the risk of gastric bleeding and worsens peptic ulcer disease

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8
Q

Concomitant administration of ascorbic acid or other antioxidants with artemisinin based combination therapy (ACT) in the treatment of malaria will lead to

A

Therapeutic failure/Reduction in efficacy

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