Drug Info Flashcards
References for identification / availability (DI)
- MIMS
- Mediview
- HSA
References for IV Infusion (DI)
- Product Insert
- Trissels (injectable Drugs)
- Paediatric Injectable drugs (Teddy bear)
References for Parental Compatibility (DI)
- Trissel’s
- King’s guide
- Lexi-Comp
References for Pregnancy & Lactation (DI)
- Briggs (drugs in pregnancy & lactation)
- Micromedex / Lexi-Comp
- Hales (lactation)
References for Dosing (DI)
- Lexi-Comp Drugs
- Micromedex
- BNF
References for choice of therapy (DI)
- Pharmacotherapy textbooks
- MOH / ACE / CLinical Societies Guidelines
- UpToDate
References for adverse drug reactions (DI)
- Micromedex
- Lexi-Comp / UpToDate
- Meyler’s Side effects of Drugs
References for Drug Interaction (DI)
- Micromedex
- Lexi-Comp
- Stockley’s Drug interaction
DI: Identification / Availability responses (4)
- Generic and brand name of drug (Spell out)
- Origin & use of drugs
- Available form & strength of drug
- Category (POM/ P+/ P / OTC)
- If not available - consider alternatives, refer to respective pharmacies/source
DI: IV infusion responses (5)
- Reconstitute
- Withdraw
- Dilute
- Time run over
- Storage
DI: Parental compatibility
- If compatible: Concentration & diluent
- If not: reason (Precipitation? Chemical degradation, data not good enough)
- Consider possibility of drug interactions between the drugs
DI: pregnancy responses (5)
- Benefit v.s risk for both mother & child
- Ratings
- Alternatives & non-pharms to limit drug use
- Monitoring
- How to minimise exposure
DI: lactation responses
- Milk to plasma ratio ( > 1 = more concentrated in milk)
- Relative Infant Dose (safe if < 10%)
DI: Dosing & Choice of therapy responses (5)
- Route
- Dose & frequency
- Dose Adjustment & max dose (impairment, weight)
- Monitoring parameters
- Administration
DI: ADR responses (7)
- Signs and Symptoms
- Frequency of ADRs
- MOA of ADR (dose-related / DDI)
- Onset? Reversible?
* If reversible - time to recovery - Management - Drug: Reduce dose, Discontinue or Switch?
- Alternatives - is it a class effect?
- Reporting to HSA - if new health product (<5 years), serious ADR or unexpected ADR
DI: Drug Interaction responses (5)
- Signs & Symptoms
- Lab changes
- MOA (categories)
- Onset, severity, duration, significance
- Alternatives
- Categories and References
DI Categories (8)
- Drug Identification and Availability
- Preparation for IV infusion
- Parenteral Compatibility
- Pregnancy
- Lactation
- Dosing and Choice of Therapy
- Adverse Drug Reactions
- Drug-Drug Interaction
References for Special Populations (Paed/Geriatric) - Dosing/Choice of Therapy
Paediatric - Lexi-Comp, BNF for children
Geriatric - Lexi-Comp
References for Special Populations (Renal) - Dosing/Choice of Therapy
- The Renal Drug Handbook
- Drug Prescribing in Renal Failure: Dosing Guideline for Adults
- Renal Pharmacotherapy: Dosage Adjustment of Medications Eliminated by The Kidneys
References for Special Populations (Hepatic) - Dosing/Choice of Therapy
- Drugs and The Liver
References for Abx Therapy
Sanford Guide to Antimicrobial Therapy
References for Enteral Feeding
Handbook of Drug Administration via Enteral Feeding Tube
Response (Lactation): Formulas
- Milk to Plasma Ratio
- < 1 –> equal transfer into milk from plasma
- > 1 –> more concentrated in milk than plasma - Relative Infant Dose (RID) = [Infant dose in milk (mg/kg/day) / Maternal dose (mg/kg/day)] x 100%
- Safe if <10%
