Drug Induced Neutropenia

Question 1

Which class of drugs used for inflammatory bowel disease (IBD) may cause neutropenia?

Answer 1

Aminosalicylates – Used for ulcerative colitis and Crohn’s disease.

Question 2

Which class of drugs used for cancer treatment is a common cause of neutropenia?

Answer 2

Cytotoxic drugs – Used in chemotherapy for cancer.

Question 3

Name two NSAIDs that can cause neutropenia.

Answer 3

Ibuprofen, Indometacin – Used for pain and inflammation.

Question 4

Which antipsychotics can cause neutropenia?

Answer 4

Phenothiazine antipsychotics eg chlorpromazine, Levomepromazine, Promazine – Used for schizophrenia and severe nausea.

Question 5

Which ACE inhibitor used for hypertension and heart failure can cause neutropenia?

Answer 5

Captopril – Used for hypertension and heart failure.

Question 6

Which vasodilator used for hypertension and heart failure can cause neutropenia?

Answer 6

Hydralazine – Used for hypertension and heart failure.

Question 7

Which atypical antipsychotic has a well-known risk of neutropenia and agranulocytosis?

Answer 7

Clozapine – Used for treatment-resistant schizophrenia.

Question 8

Name three other atypical antipsychotics that can cause neutropenia.

Answer 8

Olanzapine, Risperidone, Haloperidol – Used for schizophrenia and bipolar disorder.

Question 9

Which tricyclic antidepressant (TCA) can cause neutropenia?

Answer 9

Imipramine – Used for depression and bedwetting (enuresis) in children.

Question 10

Which mood stabilizer/antiepileptic drug can cause neutropenia?

Answer 10

Valproic acid – Used for epilepsy and bipolar disorder.

Question 11

Name three other antiepileptic drugs that can cause neutropenia.

Answer 11

Carbamazepine, Ethosuximide, Phenytoin – Used for epilepsy.

Question 12

Name three antibiotic classes that can cause neutropenia.

Answer 12

Penicillins, Cephalosporins, Sulphonamides – Used for bacterial infections.

Question 13

Which broad-spectrum antibiotic that inhibits protein synthesis can cause neutropenia?

Answer 13

Chloramphenicol – Used for bacterial infections (rarely used due to toxicity).

Question 14

Name two antimalarial drugs that can cause neutropenia.

Answer 14

Chloroquine, Atovaquone – Used for malaria treatment and prevention.

Question 15

Which fluoroquinolone antibiotic can cause neutropenia?

Answer 15

Ciprofloxacin – Used for bacterial infections.

Question 16

Which antibiotic used for anaerobic infections can cause neutropenia?

Answer 16

Metronidazole – Used for anaerobic bacterial and protozoal infections.

Question 17

Name two antiretroviral drugs used for HIV that can cause neutropenia.

Answer 17

Lamivudine, Zidovudine – Used for HIV treatment.

Question 18

Which antifungal drug used for invasive fungal infections can cause neutropenia?

Answer 18

Posaconazole – Used for fungal infections in immunocompromised patients.

Question 19

Which antiviral drug used for CMV infections can cause neutropenia?

Answer 19

Ganciclovir – Used for cytomegalovirus (CMV) infections.

Question 20

Name two antithyroid drugs that can cause neutropenia.

Answer 20

Carbimazole, Propylthiouracil – Used for hyperthyroidism.

Question 21

Which iron chelator used for iron overload disorders can cause neutropenia?

Answer 21

Deferiprone – Used for thalassemia and hemochromatosis.

Question 22

Which interleukin-1 receptor antagonist used for rheumatoid arthritis can cause neutropenia?

Answer 22

Anakinra – Used for rheumatoid arthritis and autoinflammatory disorders.

Question 23

Which drug used for gout prevention can cause neutropenia?

Answer 23

Allopurinol – Used for gout and hyperuricemia.

Question 24

Which gout medication that reduces inflammation can cause neutropenia?

Answer 24

Colchicine – Used for gout and familial Mediterranean fever.

Question 25

Which gold-containing compound used for rheumatoid arthritis can cause neutropenia?

Answer 25

Gold – Used for rheumatoid arthritis (rarely used today).

Question 26

Which disease-modifying antirheumatic drug (DMARD) used for autoimmune diseases can cause neutropenia?

Answer 26

Methotrexate – Used for rheumatoid arthritis, psoriasis, and cancer.

Question 27

Which chelator used for heavy metal poisoning and autoimmune conditions can cause neutropenia?

Answer 27

Penicillamine – Used for Wilson’s disease and rheumatoid arthritis.

Question 28

Which monoclonal antibody used for autoimmune diseases and lymphoma can cause neutropenia?

Answer 28

Rituximab – Used for lymphoma, leukemia, and rheumatoid arthritis.

Question 29

Which immunosuppressant used for organ transplants and autoimmune diseases can cause neutropenia?

Answer 29

Azathioprine – Used for organ transplant rejection prevention and autoimmune diseases.