Drug Incompatibility

Question 1

Use suspending agent

Answer 1

Insolubility:
C.P, C.T, and C H2O
_______ is insoluble with water

Question 2

Oil + Water

Answer 2

Immiscibility:
- add emulsifying agents
- add gum and prepare an emulsion

Question 3

______ insoluble in simple syrup

Answer 3

Terpin hydrate (Insolubility)

• half of the syrup is replaced by _____ and addition of a ________ agent.
  “ Shake well before use”

Question 4

Crumbling of _________

Answer 4

Ointment
Loss of water :
Add humectant ( glycerin, propylene glycol, sorbitol)

Question 5

Crystal violet is ______ compound that changes to ______ or yellow upon _______

Answer 5

• purple
• green or yellow
• acidification

Color change:
Add buffer

Question 6

Acacia + _________ =

Answer 6

Cementation:
Bismuth salts
= Cake formation

Question 7

RedOx

Answer 7

Kcl + tannic acid
( when triturated or heated together it can form explosion)
Reducing agent + oxidizing agent

Remedy:
Dispense components separately, or if mixing is necessary, the mixing should be done lightly.

Question 8

Gel formation

Answer 8

Gelatinization
Acacia + Fe salts

Question 9

Change water to alcohol

Answer 9

Precipitation:
Camphor + H2O + KBr

Question 10

Acid may be omitted

Answer 10

Precipitation
Licorice + H or H2SO4
(Sweetening principle is dissolved)

Question 11

Any one of the ingredient is omitted

Answer 11

Precipitation:
Iron + Tannic Acid
( bluish-black tannate is formed)

Question 12

Evolution of gas

Answer 12

Sodium bicarbonate, Borax, Phenol, Glycerin
(Borax decomposes in presence of glycerin to form Na metaborate and boric acid: boric acid thus formed further reacts with glucerin to form glyceryl boric acid)

Question 13

Evolution of gas Remedy

Answer 13

Ingredients should be allowed to react in an open vessel and only when the reaction is complete, should the preparation be transfered to the final container ( reaction can be hastened with hot water)

Question 14

Evolution of gas (2)

Answer 14

NaHCO3 + Bismuth subnitrate
NaHCO3 + dil H2SO4 or dil HCl
NaHCO3 + calcium chloride or MgCl2

Question 15

Precipitation (SAP)

Answer 15

Strychnine
Aromatic spirit of ammonia
Purified water
( strychnine used in an alkaloidal salt, aromatic spirit of ammonia is an alkaline substance; once mixed, insoluble strychnine is precipitated)

Question 16

Precipitation ( SAP Remedy )

Answer 16

Dissolve strychnine is half of the water and aromatic spirit of ammonia will be dissolved in the remaining portion.