Drug Excretion LO

Question 1

Name the primary routes by which drugs are excreted from the body

Answer 1

1. Renal (via kidney): primary route for most drugs 2. Biliary (feces) 3. pulmonary 4. salivary 5. mammary

Question 2

Identify the key processes and anatomical location involved in renal excretion

Answer 2

Key processes are filtration, active tubular secretion, tubular reabsorption, biotransformation. The anatomical location is glomerulus. 222

Question 3

Describe how the physicochemical properties of a drug influence its filtration, secretion, and reabsorption by the kidney

Answer 3

Filtration: number of functional nephrons, molecular weight (MW < 5000), protein binding, renal blood flow
Secretion: active tubular secretion, carrier mediated process (saturable) (competitive), active
Reabsorption by kidney:

Question 4

Plot the relationship between molecular weight and renal clearance.