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Drug-drug Interactions > Drug-drug Interactions > Flashcards

Drug-drug Interactions Flashcards

1
Q

Carbamazepine (Tegretol) -seizure, bipolar disorder

A

Effects increased by:

Erythromycin, clarithromycin, fluconazole, grapefruit juice

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2
Q

Digoxin (class V anti arrhythmias)

A

Effects increased by:
quinidine (class I anti arrhythmia)
Ginseng may increase serum digoxin levels

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3
Q

Fluoroquinolone (ex: levofloxacin, ciprofloxacin, moxifloxacin)

A

Effects decreased by:

Aluminum-, calcium-, magnesium-, and iron-containing medications

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4
Q

HMG CoA reductase inhibitors (statins)

A

Effects increased by:

Erythromycin, itraconazole, niacin, gemfibrozil, grapefruit juice

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5
Q

Lithium

A

Effects increased by:

Diuretics, NSAIDs

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6
Q

Morphine

A

Effects decreased by:

Naloxone

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7
Q

Nitrates (nitroglycerin, isosorbide dinitrate, isosorbide mononitrate)

A 
Effects increased by:
PDE5 inhibitors (sildenafil, vardenafil, tadalafil)
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8
Q

Oral contraceptives

A

Effects decreased by:

Antibiotics

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9
Q

Penicillin

A

Effects decreased by :

Probenecid (for gout)

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10
Q

Phenobarbital (seizures, anxiety)

A

Effects decreased by:

Phenytoin (for seizures)

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11
Q

SSRIs (fluoxetine, escitalopram, citalopram, etc)

A

Effects increased by:

Triptans (for headaches: rizotriptan, sumatriptan, etc)

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12
Q

TCAs (tricyclic antidepressants: nortriptyline, amitriptyline, etc)

A

Effects increased by:

SSRIs (selective serotonin reuptake inhibitors: fluoxetine, escitalopram, sertraline, etc)

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13
Q

Tetracycline (antibiotic)

A

Effects are decreased by:

Ketoconazole (antifungal), antacids, food

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14
Q

Potassium chloride

A

Effects are increased by:

Spironolactone (potassium sparing diuretic for hypertension)

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15
Q

Warfarin

A

Effects are increased by:
Ciprofloxacin, clarithromycin, aspirin, acetaminophen, NSAIDs, ginseng

Effects are decreased by:
Vitamin k, St. John’s wort, cranberry juice, broccoli, Brussels sprouts, cabbage, romaine lettuce, spinach

Ginkgo biloba may increase risk of bleeding

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16
Q

Cimetidine (Tagamet) (antihistamine &antacid)

A

Effects decreased by:

Antacids

17
Q

Ketoconazole

A

Effects decreased by:
Antacids
Mixed with echinacea may have additive hepatotoxic effects

18
Q

Levothyroxine

A

Effects decreased by:

Iron tablets

19
Q

Estrogens

A

May increase estrogen activity with black cohosh
May increase hormonal effects with ginseng
May decrease levels of estrogen with St. John’s wort
May increase effects with grapefruit juice

20
Q

Terazosin

A

May decrease effects with garlic

May decrease effectiveness of terazosin with ginseng

21
Q

NSAIDs

A

Ginkgo biloba may increase risk of bleeding

22
Q

Clopidogrel (plavix) -blood thinner

A

Ginkgo biloba may increase risk of bleeding

23
Q

Duloxetine (antidepressant, nerve pain)

A

St. John’s wort may increase adverse effects

24
Q

HIV antiviral drugs

A

St. John’s wort may increase blood concentration and effectiveness in treating HIV

25
Q

Paroxetine (paxil) SSRI

A

St. John’s wort may increase effects and risk of toxicity

26
Q

Venlafaxine (Effexor) SNRI

A

St. John’s wort may increase sedative effects

27
Q

Alprazolam (Xanax; benzodiazepine)

A

Effects increased by:

Grapefruit juice

28
Q

Amiodarone (anti arrhythmic)

A

Effects increased by: grapefruit juice

29
Q

Atorvastatin

A

Effects increased by grapefruit juice

30
Q

Calcium channel blockers (amlodipine, diltiazem, nifedipine, etc)

A

Effects increased by grapefruit juice

31
Q

Central nervous stimulants (methylphenidate, modafinil, vyvanse, dextroamphetamine, etc)

A

Effects increased with caffeine

32
Q

Griseofulvin (antifungal)

A

Effects increased by fatty foods

33
Q

Losartan (angiotensin II receptor antagonist; hypertension)

A

Effects decreased by grapefruit juice

Drug-drug Interactions (1 decks)

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