Drug Dosages

Question 1

Metformin

Answer 1

Initial: 500 mg PO BID
Clinical MAX: 2 g TDD
PPI MAX: 2,550 mg TDD

Question 2

Glimepiride

Answer 2

Initial: 1-2 mg daily

1-8 mg daily

Question 3

Glipizide

Answer 3

Initital: 2.5-5 mg daily AC

2.5-40 mg daily AC

Question 4

Glipizide XL

Answer 4

Initial: 2.5-5 mg daily

2.5-20 mg daily

Question 5

Glyburide

Answer 5

Initial:1.25-5 mg daily

1.25-20 mg daily

Question 6

Glyburide Micronized

Answer 6

Initial: 1.5-3 mg daily

1.5-12 mg daily

Question 7

Repaglinide

Answer 7

Initial: A1c less than 8%: 0.5 mg AC
A1c more than 8%: 1 mg AC
4-16 mg TDD

Question 8

Nateglinide

Answer 8

Initial: A1c less than 8%: 60 mg AC
A1c more than 8%: 120 mg AC
180-360 mg TDD

Question 9

Rosglitazone

Answer 9

Initial: 2-4 mg daily/BID

4-8 mg TDD

Question 10

Pioglitazone

Answer 10

Initial: 15-30 mg daily

15-45 mg daily

Question 11

Metformin XL

Answer 11

Initial: 1000 mg daily

1-2 g daily

Question 12

Acarbose

Answer 12

Initial: 25 mg AC
50-300 mg TDD
MUST titrate dose

Question 13

Miglitol

Answer 13

Initial: 25 mg AC
50-300 mg TDD
MUST titrate dose

Question 14

Sitagliptin

Answer 14

Initial: 100 mg daily
CrCl 30-50: 50 mg daily
CrCl below 30: 25 mg daily

Question 15

Saxagliptin

Answer 15

Initial: 5 mg daily

CrCl below 50: 2.5 mg daily

Question 16

Linagliptin

Answer 16

Initial: 5 mg daily

NO renal adjustment necessary

Question 17

Alogliptin

Answer 17

25 mg daily
CrCl 30-60: 12.5 mg daily
CrCl below 30: 6.25 mg

Question 18

Canagliflozin

Answer 18

Initial: 100 mg daily
MAX: 300 mg daily
CrCl 45-60: 100 mg daily MAX
CrCl beow 45: D/C

Question 19

Dapagliflozin

Answer 19

Initial: 5 mg daily
MAX: 10 mg daily
CrCl below 60: D/C

Question 20

Empagliflozin

Answer 20

Initial: 10 mg daily
MAX: 25 mg daily
CrCl below 45: D/C

Question 21

Exenatide (Byetta)

Answer 21

5 mcg BID SC prior to AM/PM meals

Question 22

Liraglutide

Answer 22

0.6 mg daily SC for one week, then 1.2 mg daily

MAX: 1.8 mg daily

Question 23

Albiglutide

Answer 23

30 mg weekly SC

MAX: 50 mg weekly

Question 24

Pramlintide

Answer 24

T1DM: 15-60 mcg SC
T2DM: 60-120 mcg

Question 25

Exenatide (Bydureon)

Answer 25

2 mg weekly SC