Drug Distribution and Toxicity

Question 1

A ligand that binds to receptors and thereby alters the proportion of them that are active, resulting in a biological response is called a(n) _______.

Answer 1

agonist.

Question 2

What is the formula for therapeutic index?

Answer 2

LD50/ED50

Question 3

What is a partial agonist?

Answer 3

A drug that, no matter how much is given, cannot achieve the same efficacy as a complete agonist.

Question 4

Can a competitive antagonist be overcome by administering more agonist?

Answer 4

Yeah

Question 5

The degree to which different agonists produce varying responses even when occupying the same proportion of receptors is called _______.

Answer 5

efficacy.

Question 6

In which organ(s) are CYP 2D6 enzymes located?

In which organ(s) are CYP3A enzymes located?

Answer 6

2D6 are in the liver only.

3A are in both the liver and GI mucosa.

Question 7

What do the CYP2D6 enzymes do to codeine?

Answer 7

Convert it to morphine.