Drug Discovery (Week 13)

Question 1

pharmacogenetics/pharmacogenomics

Answer 1

• idea that drug responses in a population will vary due to differences in genetic makeup (SNPs)
• predict individual responses
• p.genetics=single gene
• p.genomics=multiple genes/expn patterns

Question 2

Clinical Trial Processes Phases

Answer 2

I: Pharmacokinetics, dosing, safety. small, short study, healthy + patients. Open label, no control.
II: efficacy, safety and pharmacokinetics. controlled, usu blinded. medium size, patients.
III: efficacy, safety (rare issues). large group, patients:
Success = NOC = approved for sale
IV: post marketing surveillance, may be required. Monitor for safely issues + efficacy.

Question 3

old vs new drug discovery methods

Answer 3

old: natural products or mimick endogenous thing
new: high-throughput screening, combinatorial chemistry, reliance on pharmacogenetics