Drug discovery/medchem

Question 1

What is phosphorylation?

Answer 1

Essential in cell processes’ metabolism, transcription, cell growth, differentiation, cell movement, apoptosis, immune fxns, etc.

Question 2

What is Lipinski’s rule of five?

Answer 2

1. <5 H bond donors
2. Molecular weight <5090
3. LogP less than 5
4. <10 H bond acceptors