Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

High yield > Drug deck > Flashcards

Drug deck Flashcards

1
Q

What receptors do classical antipsychotics act on?

A

D2, M1, H1, α1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Give 2 examples of a classical antipsychotic

A

Haloperidol

Chlorpromazine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Where do atypical antipsychotics act?

A

5HT2, D2 has some H1, M1 and α1 effects too

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Why use atypical antipsychotics?

A

Better at dealing with negatve symptoms of SCZ also less extrapyrimdal side effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the gold standard antipsychotic?

A

Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What condition are patients at risk of with long term classical antipsychotic use?

A

Tardive dyskinesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MOA of statins

A

Inhibition of HMG-CoA reductase resulting in less LDL and a mild increase in HDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

SE of statins

A

Myopathy

Rhabdomyolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA of NSAIDs

A

COX inhibitors leading to reduction in production of prostagladins and thromboxane A2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SE of NSAIDs

A 
Hyperkalaemia
Bronchospam
Peptic ulcer
Hepatotoxic
Ototoxicity
Reduced GFR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SE of morphine

A

Respiratory depression
Urinary retention
Constipation
N+V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

MOA of COCP

A

Inhibits ovulation via inhibition of HPG axis via release of oestrogen + progestogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

3 Adv of COCP

A

Reliable
Reversible
Cycle control

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Absoulte CI for COCP (3 of many)

A

Breastfeeding up to 6 weeks post partum
Up to 3 weeks post-partum with other risk factors for VTE
Age >35 and smoker >15 cigarettes a day
Blood pressure >160/100
Ischaemic heart disease or stroke or vascular disease (ever)
Personal history of DVT (ever)
Thrombogenic mutation (e.g. factor V leiden)
Major surgery with immobilisation
Atrial fibrillation
Migraine with aura within the last 5 years
Breast cancer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of Progesterone contraception

A

May inhibit ovulation
Thickened and viscid cervical mucus
Endometrium unstable for implantation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Cons of progesterone contraception

A

Amenorrhoea/ irregular bleeding
Taken at same time each day (cerazette 12 hours)
Increased risk functional ovarian cysts
If did get pregnant increased risk ectopic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What class of antibiotics target the bacterial cell wall?

A

Beta-lactams - Penicillins, cephalosporins, carbapenems, glycopeptides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What class of antibiotic targets RNA and protein synthesis

A

Macrolides
Lincosamides
Tetracyclines
Aminoglycosides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What class of antibiotic targets DNA structure and function?

A

Quinolones
Nitroimidazoles
Nitrofurantoin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What class of antibiotic targets Folic acid synthesis?

A

Antifolates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Give 4 examples of penicllins

A

Penicillin
Amoxicillin (enhanced uptake)
Flucloxacillin (penicillinase - resistant
Co-amoxiclav (beta-lactamase inhibitor)
Piperacilin-tazobactam (anti-pseudomonal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Give 4 examples of cephalosporins

A

Cephalexin (1st gen)
Cefuroxime (2nd gen)
Cefotaxime (3rd gen)
Ceftriaxone (4th gen)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Give 2 examples of carbapenems

A

Meropenem

Ertapenem

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Give 2 examples of glycopeptides

A

Vancomycin

Teicoplanin

25
Q

Give 2 examples of macrolides

A

Erythromycin

Clarithromycin

26
Q

Give an example of a lincosamide

A

Clindamycin

27
Q

Give an example of an aminoglycoside

A

Gentomycin

28
Q

Give 2 quinolones

A

Ciprofloxacin

Levofloxacin

29
Q

Give an exmaple of a nitroimidazole

A

Metronidazole

30
Q

MOA and use of nitrofurantoin

A

Targets bacterial DNA synthesis

Used in uncomplicated UTIs

31
Q

2 examples of anti-folates

A

Trimethoprim, sulphoamides

32
Q

1st line antibiotic for CAP

A

Amoxicillin

33
Q

1st line antibiotic for soft tissue infection

A

Flucloxacillin

34
Q

Best antibiotic for an anaerobic infection e.g. abscess?

A

Metronidazole (Nitroimidazole) - bacteriostatic

35
Q

1st line treatment for bacterial sore throat if centor criteria are met?

A

Penicillin V

36
Q

What are the 4 TB drugs?

A

Rifampicin
Isoniazid
Pyrazimide
Ethambutol

37
Q

SE of the TB drugs

A

Hepatotoxicity

38
Q

Give 2 examples of DNA polymerase inhibitors

A

Aciclovir, Ganciclovir

39
Q

MoA of Aciclovir

A

Virus replication blockade via inhibition of DNA polymerase

40
Q

Indication for Aciclovir

A

Severe chickenpox
Shingles
Herpes encephalitis

41
Q

What class of drug does ritonavir belong to?

A

Viral protease inhibitor

42
Q

MoA of ritonavir

A

Blockade of viral protease required for virus particle assembly

43
Q

Give an example of a viral fusion inhibitor

A

Enfuvirtide

44
Q

MoA of Enfuvirtide

A

Blockade of virus fusion to target cell membrane

45
Q

What class of drug is Maraviroc?

A

Viral entry inhibitor

46
Q

MoA of Maraviroc

A

Blockade of HIV binding to co-factor for cell entry

47
Q

MoA of fluconazole

A

Disruption of fungal membrance function

48
Q

Name 2 taxanes

A

Paclitaxel

Docetaxel

49
Q

Give an example of a classical alkylating agent

A

Cyclophosphamide

50
Q

Give 2 platinum compouds

A

Cisplatin

Carboplatin

51
Q

MoA of alkylating agents

A

DNA crosslinking

52
Q

SE of anti-neoplastic drugs

A

Hair loss
Bone marrow supression
Nausea

53
Q

Name 2 vinca alkaloids

A

Vincristine

Vinblastine

54
Q

MoA of Taxanes and vinca alkaloids

A

Inhibition of microtubule assembly in mitotic spindle

55
Q

Name 2 topoisomerase inhibitos

A

Bleomycin

Etopside

56
Q

MoA of bleomycin

A

Inhibition of DNA topoisomerase

57
Q

What class do fluorouracil and cytarabine belong to?

A

Antipyrimidines

58
Q

What class do mercaptopurine and thioguanine belong to?

A

Antipurines

59
Q

MoA of antipyrimidines and antipurines

A

Inhibition of RNA and DNA synthesis

High yield (2 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions