drug clearance and elimination of half life Flashcards
what is the principal organ for drug elimination
the kidneys
what is drug elimination mostly accomplished by
renal filtration of blood plasma
what is reabsorbed into blood circulation in the renal tubes
Water and most electrolytes
what is clearance (CL)
an expression of the elimination of a drug from the body
more specifically: the volume of blood removed (or cleared) of drug per unit of time
what does CL do
determine the dosage rate needed to maintain a desired [D]plasma
when does a steady state exist
exists when the Rate of Drug Administration (R0) = Rate of Drug Elimination (RE)
what does the elimination half life depend on
the volume of distribution and clearance
what does elimination half life do
- place major constraints on the dosage regimen
- determines the time required for [Drug]Plasma to achieve [Drug]PlasmaSS
- determines how much time is required for drug to be eliminated from body
how many half lives are normally required to reach a steady state
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