Drug Classes Indications and Mechanisms

Question 1

Bind transpeptidases and inhibit peptidoglycan cross-linking –> inhibit bacterial cell wall synthesis

Answer 1

B-lactams
penicillin, cephalosporin, carbapenem

Question 2

Side effects:
- HSRs
- Direct Coombs + hemolytic anemia
- Drug-induced interstitial nephritis

Answer 2

Penicillin

Question 3

Bacterial B-lactamases that cleave B-lactam ring; altered PBPs

Answer 3

Mechanisms of B-lactam resistance

Question 4

Side effects:
- HSTs
- Autoimmune hemolytic anemia
- Disulfiram-like reaction
- Vitamin K deficiency

Answer 4

Cephalosporins

Question 5

Side effects:
- GI distress
- Rash
- CNS toxicity at high levels

Answer 5

Carbapenem

Question 6

Inhibits