Drug Classes and Targets

Question 1

Which 3 drugs are considered muscarinic receptor agonists for the test?

Answer 1

1. Bethanechol
2. Acetylcholine
3. Pilocarpine

When you want somone to rest you BAP them directly on the head and lay them on their Pilo

Question 2

What is the class and site of action for ATROPINE?

Answer 2

• Muscarinic Receptor Antagonis
  
  • Fixes Sludge BB
  • May cause overheading due to decreased sweat.

Question 3

Which drugs inhibit AChE?

Answer 3

Say “NOPE” to mustard gas

1. Neostigmine (NeO CNS=NO CNS)
2. Organophosphates (sarin gas)
3. Physostigmine (goes to all physiology)
4. Edrophonium ( Pedro calls on the phone to report mustard gas, cant say his full name)

Question 4

How do you treat AChE inhibitor poisoning (organophosphate poisoning)?

Answer 4

Atropine + Pralidoxime (AChE reactivator)

Question 5

What is the target for Epinephrine?

Answer 5

It is nonselective Alpha and Beta agonist.

Question 6

Why would i use Norepinephrine instead of Epinephrine?

Answer 6

If you want to avoid B2 effects

Norepi is A1 A2 and B1

Question 7

Which drug would I want to use if I wanted to increase constriction of bloodvessels, GI/GU, and dilate my pupil?

Answer 7

Phenylephrine- α1 (selective)

The -“ephrines”

Epi-all 4

Norepi-minus B2

Phenyl- only A1

Question 8

Which drug would somone take to seletively decrease sympathetic outflow?

Answer 8

Clonidine (A2 selective)

Clonidine is the “chill pill” for (ADHD and Anxiety=A2)

Question 9

Which drug nonselectively agonizes B receptors?

Answer 9

Isoproterenol (B1,2 nonselective) B>A

Epi B=A

Norepi A>B

Question 10

If I am having an asthma attack and I want to dilate my airways, which drug do I use and which receptor does it act on?

Answer 10

Albuterol (B2)

Question 11

Which drug is a D1-D2 direct agonist PLUS indirect (releaser) agonist?

Answer 11

Dopamine

Question 12

Which drug is an indirect alpha agonist (releaser)?

Answer 12

Pseudoephedrine

although wiki claims it is a direct agonist.

Question 13

Which drugs are agonists for only A1, A2, B1, and B2 respectively?

Answer 13

A1- Phenylephrine

A2- Clonidine

B1- Dobutamine *(not required for test)

B2- Albuterol

Question 14

Which drugs inhibit only A1, A2, B1, and B2 respectively?

Answer 14

Trick question only A1 and B1 can be selectively inhibited.

• DoxAzosIn (A1)
• Metoprolol (B1) (only 1 B… i mean P)

Propanolol (B1/B2… has 2 Ps— not needed for test)

Question 15

Which drug inhibits all alpha and Beta receptors?

Answer 15

L-A-Beta-lol

Labetalol does all alpha and beta…lol

Question 16

Say you eat a can of old peaches… what toxin might i find and how does it work?

Answer 16

Botulinum toxin, which inhibits ACH release by chewing up SNAP protiens.

Question 17

How does Black Widow venom work?

Answer 17

Increases ACh release.

Question 18

Which drug (s) is a NMJ competitive blocker (non-depolarizing)?

Answer 18

Curare and curare type drugs.

Need to know:

1. Atacurium
2. Rocuronium (ro for roids as it is a steroid derivative)

Question 19

Which drug (s) is a NMJ depolarizing blocker?

Answer 19

Succinylcholine (two ACh molecules stuck together.)