Drug classes

Question 1

broad spectrum coverage GN,GP…. but not enterococcus

Answer 1

sulfonamides

Question 2

usefulness limited by numerous interactions with common drugs. hepatotoxic.

Answer 2

rifamycins

Question 3

use limited to very defined indications due to resistance

Answer 3

rifamysins

Question 4

only beta-lactam with activity against MRSA

Answer 4

cephteroline (4th gen cephalosporin)

Question 5

dosing is once daily depending on weight and nature of infection

Answer 5

daptomycin

Question 6

side effect profile fairly benign

Answer 6

daptomycin

Question 7

bactericidal (5)

Answer 7

beta-lactams, fluoroquinolones, vancomysins, rifamycin, daptomycin

Question 8

bacteriostatic (6)-longer recovery time

Answer 8

sulfonamides, macrolides, aminoglycosides, lincomysins, linezolids, tetracyclines

Question 9

spectrum includes most GP organsims. only available in IV form.

Answer 9

daptomysin

Question 10

MOA: destabilizes cell membrane

Answer 10

daptomycin

Question 11

cyclic lipopeptide

Answer 11

daptomycin

Question 12

potentially significant drug-food interactions (seratonin, catecholamine)

Answer 12

linezolids

Question 13

use limited to institutional settings. available as IV or PO (same dosing).

Answer 13

linezolid

Question 14

oxazolidinone

Answer 14

linezolids

Question 15

spectrum is GP’s, aerobes.

Answer 15

linezolids

Question 16

Hazard of ear and renal toxicity; must blood monitor (usually inpatient). poor absorption due to complexity.

Answer 16

vancomysins

Question 17

dosing protocols and chemical structure similar to aminoglycosides

Answer 17

vancomysins

Question 18

MOA: inhibits cell wall synthesis

Answer 18

vancomysins

Question 19

Spectrum: GN aerobes

Answer 19

aminoglycosides

Question 20

why are aminoglycosides used with beta lactams

Answer 20

to decrease resistance and enhance efficacy

Question 21

Risk of severe side effects

Answer 21

sulfonamides

Question 22

MOA: inhibits proteins synthesis by binding the 30S subunit

Answer 22

aminoglycosides

Question 23

Hazard of ear and renal toxicity; must blood monitor (usually inpatient). available IV and topical.

Answer 23

aminoglycosides

Question 24

MOA: suppresses RNA synthesis

Answer 24

rifamycins

Question 25

Spectrum: susceptible GP’s and a few GN’s. no anaerobes.

Answer 25

rifamycins

Question 26

distributes rapidly to the CNS

Answer 26

rifamycins

Question 27

orange pee

Answer 27

rifamycins

Question 28

antiprotazoal and anti-anaerobic. available by IV or PO.

Answer 28

metronidazole

Question 29

spectrum: susceptible GN aerobes

Answer 29

nitrofurantoin

Question 30

do not use with CrCl

Answer 30

nitrofurantoin

Question 31

The penicillin classes (3)

Answer 31

Pen G, anti-staphylococcal, extended spectrum

Question 32

Used for coag-neg staph, strep pyo.

Answer 32

Pen G derivatives

Question 33

dihydropeptidase inhibition of cell wall synthesis

Answer 33

beta lactams

Question 34

used in TB and meningitis

Answer 34

rifamycin