Drug Biotransformation

Question 1

________, ________, and ________ are all anticonvulsants that cause enzyme induction.

Answer 1

Barbiturates, Carbamazepine (Tegretol), Phenytoin (Dilantin)

Question 2

________ is an antibiotic that causes enzyme induction.

Answer 2

Rifampin (Rimactane)

Question 3

________ is an antidepressant that causes enzyme induction.

Answer 3

St. John’s Wort

Question 4

________ and ________ are environmental carcinogens that can cause enzyme induction.

Answer 4

Benzpyrene, PCBs (polychlorinated biphenyls)

Question 5

________ is an antihistamine that can cause enzyme inhibition.

Answer 5

Cimetidine (Tagamet)

Question 6

________ and ________ are antibiotics that can cause enzyme inhibition.

Answer 6

Ciprofloxacin (Cipro), Erythromycin (Ilosone)

Question 7

________ is an antifungal that can cause enzyme inhibition.

Answer 7

Ketoconazole (Nizoral)

Question 8

________ and ________ for HIV are two other drugs that can cause enzyme inhibition.

Answer 8

Oral contraceptives, protease inhibitors