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Psychiatry > Drug and receptor facts > Flashcards

Drug and receptor facts Flashcards

1
Q

indication: pain syndromes

A

amitriptyline, duloxetine

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2
Q

indication: OCD

A

clomipramine

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3
Q

indication: enuresis

A

imipramine

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4
Q

indication: elderly depression

A

nortriptyline, mirtazapine

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5
Q

mechanism: mirtazapine

A

alpha 2 antagonist; alpha 2 is presyn and inhibitory, so an antagonist to alpha 2 results in more 5HT / NE release into synapse; very anti-H at low doses –> sleepiness + weight gain

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6
Q

5HT 1a receptor

A

more serotonin –> relief of depression sxs

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7
Q

5HT 2a/c receptor

A

more serotonin –> decline in libido, insomnia, headache, jitters

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8
Q

5HT 3/4 receptor

A

more serotonin –> N/V, GI upsets

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9
Q

mechanism: nefazodone

A

5HT 2a receptor antagonist (so reduced incidence of sexual side effects) + partial alpha 1 / 5HT 1a receptor agonist + slight reuptake inhibitor

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10
Q

side effects: nefazodone

A

liver toxicity, so rarely used; dry mouth, somnolence, nausea, dizziness, blurred vision, weakness, confusion, orthostatic hypotension

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11
Q

mechanism: trazadone

A

5HT (especially 2a) receptor antagonist (antagonizes all 5HT other than 5HT 1a, where it is a partial agonist), less weight gain b/c little effect on 2c, some alpha and histamine antagonism –> does cause sleepiness

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12
Q

side effects: lithium

A

neurotoxicity, leukocytosis, hypothyroid, diabetes insipidus, GI, teratogen (Ebstein’s anomaly)

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13
Q

Ebstein’s anomaly

A

teratogenicity of lithium; septal leaflet of tricuspid displaced toward RV apex

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14
Q

side effects: carbamezapine

A

SJS rash, CBC abnormalities. autoinducer of liver means it induces its own metabolism and that of VPA, so need to increase dose to maintain blood concentrations over time. teratogenicity: craniofacial defects

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15
Q

side effects: valproic acid

A

hepatitis, CBC abnormalities, sedation, weight gain. teratogenicity: neural tube defects

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16
Q

mechanism, indications, and side effects: lamotrigine

A

MOA: sodium channel blocking anti-epileptic
indications: prevention of depression, mood stabilization in bipolar
side effects: SJS rash

17
Q

ativan: potency

A

equal IM / IV / PO

18
Q

benzos not metabolized by liver

A

LOT: lorazepam, oxazepam, temazepam

19
Q

pharm treatment: Tourette’s

A

risperidone, alpha 2 agonists (clonidine, guanfacine). if severe, haldol, pimozide. if co-morbid ADHD, use of stimulants controversial. if co-morbid OCD, good response to SSRI + antipsychotic

Psychiatry (3 decks)

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