Drug Action Flashcards
what are the 4 main modes of drug action
activation or blocking of receptors, activation or blocking of enzyme function, opening or blocking ion channels, facilitating or blocking transport systems
what is affinity
the tightness of the drug binding to the receptor
what is occupancy
how much time the drug spends on the receptor
what is efficacy
how effective the drug is at producing a response from the receptor
what is an agonist
binds to receptor to cause an effect
what is a partial agonist
more difficult to produce the drug/receptor effect than with an agonist
what are the two types of antagonists?
competitive and non-competitive
what is a reversible antagonist
antagonist effect reduced by increasing the concentration of the agonist
what is an irreversible antagonist
binds and reduces available receptors for the agonist
what can ion channels change?
cell electrical activity and ion influx
what does an antagonist do?
bind to receptors and don’t cause an effect
what is the relationship between occupancy, affinity and efficacy
occupancy and affinity affect drug efficacy
