Drug Action - 1.3

Question 1

Receptors

Answer 1

molecule or complex of molecules located on outside or inside of cell with regulatory role in homeostatic control of organism.

• normally bound and activated by endogenous ligands (substances found in body like hormones and neurotransmitters)

Question 2

Location of receptors determines what?

Answer 2

Where a drug will act and whether response that results from drug-receptor interaction is beneficial or detrimental

Question 3

Agonists

Answer 3

drugs that bind to and stimulate a receptor

Question 4

Antagonists

Answer 4

drugs that bind to but block response at receptor

Question 5

Lock and Key analogy

Answer 5

Lock - receptor

Key - drug

Question 6

Dose-receptor relationship

Answer 6

intensity of pharmacological effects produced by drug increases in proportion to the dose

Question 7

Dose

Answer 7

amount of drug taken

Question 8

Efficacy

Answer 8

Maximum pharmacological response produced by specific drug in that biological system

Question 9

Potency

Answer 9

dose of a drug required to produce response of a certain magnitude

• refers to only amount of drug that must be given to obtain particular response

Question 10

The range of plasma concentrations where the drug is effective but toxicities usually do not occur

Answer 10

Therapeutic Range