Dr. P's Lytes Flashcards
D5W
- 5% Dextrose in H2O
- HYPOTONIC
- Osmolality = 250
- 50gm/L of glucose
- 170cal
- Used to replace free body water
- Can be used in tx of hypernatremia
- Or TKO IVs
Normal Saline
- 154 mEq/l Cl
- 154 mEq/l Na
- 0.9%NaCl
- ISOTONIC
- Osmolality = 300
- Used to replace total circulating volume
- Only fluid you can use with blood products
- Replaces NaCl deficit
Lactated Ringers
- Na, Cl, K (4), Ca (4), Bicarb (in the form of lactate)
- ISOTONIC
- Osmolality = 270
- Used to replace total circulating volume
Human Cell Tonicity
275-290
Isotonic Solutions tonicity
240-340 mOsm/L
Hypotonic Solutions tonicity
<240mOsm/L
Hypertonic Solutions tonicity
> 340mOsm/L
ANP mechanism?
Increased Na+ secretion
Increase Aldosterone?
Increase Sodium uptake
Serum Na+ think…
H2O
Extracellular volume think…
Na+
Acute Hyponatremia
massive intake of H2O (drinking contest)
Persistant Hyponatremia due to….(2)
- Oral or IV intake of water that can’t be excreted
- SIADH
- Reduced circulating blood volume: diarrhea, vomiting
- Renal or heart failure
CNS symptoms with extreme hyponatremia (<120)
stupor, seizures, coma
Urine Na+ magic number?
20meq/l
Urine Na+ with depleted circulating blood volume?
<20meq/l
Urine Na+ with SIADH?
Normal at >40meq/l
Hypotonic Hyponatremia
Too much H2O!! Caused by:
- IV fluids
- Water intox
- SIADH
Rapid correction of hyponatremia could result in?
Central Pontine Demyelination Syndrome
Tx for life threatening hyponatremia?
1) Bring pt to 125 with hypertonic saline (3%)
2) then proceed slowly…48-72hrs
Hypertonic Hyponatremia
Increase of another solute --> Increase of H2O --> Decrease serum Na+ Causes: 1. hyperglycemia 2. mannitol 3. serum lipids
Hypernatremia symptoms
lethargy, irritability, seizures, coma, “dehydration” = water deficit,
Rapid Correction of hypernatremia?
cerebral edema
Diabetes Insipidus
peeing out water!