Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Molecular Biology of the Cell > Dr Maqsood Cell Junctions Slide 04 Rev 1 > Flashcards

Dr Maqsood Cell Junctions Slide 04 Rev 1 Flashcards

1
Q

What is the primary role of integrins in animal cells? A) Signal transduction B) Binding to the extracellular matrix C) Cell division D) Energy production

A

B) Binding to the extracellular matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which integrin is specifically associated with hemidesmosomes in epithelia? A) α5β1 B) α6β4 C) αLβ2 D) αIIbβ3

A

B) α6β4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What extracellular matrix component does the α6β4 integrin bind to in hemidesmosomes? A) Fibronectin B) Collagen C) Laminin D) Fibrinogen

A

C) Laminin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which adaptor protein links α6β4 integrin to keratin filaments in hemidesmosomes? A) Vinculin B) Plectin C) Plakoglobin D) ZO-1

A

B) Plectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What phenotype results from mutations in the α6 subunit of the α6β4 integrin? A) Muscular dystrophy B) Severe skin blistering C) Bleeding disorders D) Leukocyte adhesion deficiency

A

B) Severe skin blistering

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which integrin is ubiquitous and binds to fibronectin? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

A

A) α5β1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the consequence of mutating the β1 subunit in the α5β1 integrin? A) Skin blistering B) Early embryonic death C) Bleeding disorders D) Muscular dystrophy

A

B) Early embryonic death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which integrin is critical for platelet aggregation? A) α5β1 B) α6β4 C) αIIbβ3 D) αLβ2

A

C) αIIbβ3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What condition is associated with mutations in the αIIbβ3 integrin? A) Pemphigus B) Glanzmann disease C) Leukocyte adhesion deficiency D) Muscular dystrophy

A

B) Glanzmann disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Which integrin binds to ICAM1 on white blood cells? A) α5β1 B) αLβ2 C) α6β4 D) α7β1

A

B) αLβ2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the primary function of hemidesmosomes in epithelial cells? A) Cell communication B) Anchoring to basal lamina C) Barrier formation D) Mechanical strength

A

B) Anchoring to basal lamina

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What cytoskeletal component is linked to hemidesmosomes? A) Actin filaments B) Keratin filaments C) Microtubules D) Myosin filaments

A

B) Keratin filaments

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which protein is NOT an adaptor protein in hemidesmosomes? A) Plectin B) BP230 C) Vinculin D) None of the above

A

C) Vinculin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the primary component of the plant cell wall? A) Collagen B) Cellulose microfibrils C) Laminin D) Fibronectin

A

B) Cellulose microfibrils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which polysaccharide cements adjacent plant cell walls together? A) Cellulose B) Pectin C) Hemicellulose D) Lignin

A

B) Pectin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the role of the middle lamella in plant cells? A) Provides tensile strength B) Cements adjacent cell walls C) Regulates transport D) Supports plasma membrane

A

B) Cements adjacent cell walls

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which structure in plants is analogous to gap junctions in animals? A) Desmosomes B) Plasmodesmata C) Tight junctions D) Adherens junctions

A

B) Plasmodesmata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

What is the approximate molecular mass limit for molecules passing through plasmodesmata? A) 200 daltons B) 800 daltons C) 1500 daltons D) 3000 daltons

A

B) 800 daltons

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What structure within plasmodesmata is derived from the endoplasmic reticulum? A) Cytoplasmic sleeve B) Desmotubule C) Plasma membrane D) Cellulose microfibril

A

B) Desmotubule

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Which component of the plant cell wall provides high tensile strength? A) Pectin B) Cellulose microfibrils C) Hemicellulose D) Glycoproteins

A

B) Cellulose microfibrils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the primary role of the plant cell wall? A) Cell communication B) Structural support C) Nutrient transport D) Signal transduction

A

B) Structural support

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Which junctional complex includes adherens junctions, tight junctions, and desmosomes? A) Gap junction complex B) Epithelial junctional complex C) Hemidesmosome complex D) Plasmodesmata complex

A

B) Epithelial junctional complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the calcium-dependent adhesion protein in cell-cell junctions? A) Integrin B) Cadherin C) Connexin D) Claudin

A

B) Cadherin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Which protein family mediates cell-cell junction formation? A) Integrins B) Cadherins C) Selectins D) Claudins

A

B) Cadherins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Which protein family mediates cell-matrix junction formation? A) Cadherins B) Integrins C) Connexins D) Occludins

A

B) Integrins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Are adherens junctions and desmosomes types of cell-cell junctions? A) True B) False

A

A) True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What promotes the initial formation of adherens junctions? A) Calcium concentration changes B) Actin filament degradation C) Microtubule assembly D) Glucose transport

A

A) Calcium concentration changes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is a proteoglycan? A) A lipid molecule B) A protein with glycosaminoglycan chains C) A type of integrin D) A cellulose microfibril

A

B) A protein with glycosaminoglycan chains

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

What is the simplest glycosaminoglycan? A) Chondroitin sulfate B) Heparan sulfate C) Hyaluronan D) Keratan sulfate

A

C) Hyaluronan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Are connexins part of tight junctions? A) True B) False

A

B) False

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What are plant cell wall microfibrils primarily made of? A) Collagen B) Cellulose C) Pectin D) Lignin

A

B) Cellulose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Which component of the plant cell wall includes a linear chain of glucose residues? A) Pectin B) Hemicellulose C) Cellulose D) Glycoproteins

A

C) Cellulose

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What are gap junctions in plants called? A) Desmosomes B) Plasmodesmata C) Tight junctions D) Adherens junctions

A

B) Plasmodesmata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Which integrin state is characterized by poor ligand binding? A) Active B) Inactive C) Extended D) Aggregated

A

B) Inactive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What mechanism activates integrins by extracellular ligand binding? A) Inside-out B) Outside-in C) Transmembrane D) Cytoplasmic

A

B) Outside-in

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Which protein triggers integrin activation in platelets via the coagulation cascade? A) Fibrinogen B) Thrombin C) Rap1 D) ICAM1

A

B) Thrombin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is the role of Rap1 in integrin activation in platelets? A) Inhibits aggregation B) Promotes active integrin state C) Degrades fibrinogen D) Binds to ICAM1

A

B) Promotes active integrin state

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Which integrin is associated with muscular dystrophy when mutated? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

A

C) α7β1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

What is the primary ligand for the α7β1 integrin? A) Fibronectin B) Laminin C) Fibrinogen D) ICAM1

A

B) Laminin

40
Q

Which condition results from mutations in the αLβ2 integrin? A) Glanzmann disease B) Leukocyte adhesion deficiency C) Skin blistering D) Muscular dystrophy

A

B) Leukocyte adhesion deficiency

41
Q

What is the primary function of the desmotubule in plasmodesmata? A) Provides structural support B) Facilitates molecular transport C) Connects endoplasmic reticulum D) Regulates calcium flow

A

C) Connects endoplasmic reticulum

42
Q

Which component of the plant cell wall is embedded in a pectin matrix? A) Collagen B) Cellulose microfibrils C) Laminin D) Fibronectin

A

B) Cellulose microfibrils

43
Q

What is the primary role of pectin in the plant cell wall? A) Provides tensile strength B) Cross-links cellulose microfibrils C) Cements adjacent cells D) Regulates transport

A

C) Cements adjacent cells

44
Q

Which integrin is NOT associated with epithelial tissues? A) α6β4 B) α6β1 C) αLβ2 D) α5β1

45
Q

What is the consequence of mutating the β3 subunit in the αIIbβ3 integrin? A) Skin blistering B) Bleeding disorders C) Muscular dystrophy D) Leukocyte adhesion deficiency

A

B) Bleeding disorders

46
Q

Which protein is NOT part of the hemidesmosome structure? A) α6β4 integrin B) Plectin C) BP230 D) Claudin

A

D) Claudin

47
Q

What is the primary function of cellulose microfibrils in the plant cell wall? A) Nutrient storage B) Tensile strength C) Cell adhesion D) Signal transduction

A

B) Tensile strength

48
Q

Which structure in plasmodesmata is lined with plasma membrane? A) Desmotubule B) Cytoplasmic sleeve C) Cellulose microfibril D) Pectin matrix

A

B) Cytoplasmic sleeve

49
Q

What is the primary role of the plant cell wall in fluid transport? A) Blocks all transport B) Provides channels for fluid movement C) Stores nutrients D) Inhibits cell growth

A

B) Provides channels for fluid movement

50
Q

Which integrin is critical for leukocyte recruitment? A) α5β1 B) αLβ2 C) α6β4 D) αIIbβ3

51
Q

What is the primary ligand for the α5β1 integrin? A) Laminin B) Fibronectin C) Fibrinogen D) ICAM1

A

B) Fibronectin

52
Q

Which component of the plant cell wall is highly cross-linked? A) Cellulose B) Pectin C) Hemicellulose D) Glycoproteins

53
Q

What is the primary function of plasmodesmata in plants? A) Mechanical strength B) Cell communication C) Barrier formation D) ECM attachment

A

B) Cell communication

54
Q

Which integrin is associated with defects in somites when mutated? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

55
Q

What is the consequence of mutating the α7 subunit in the α7β1 integrin? A) Skin blistering B) Muscular dystrophy C) Bleeding disorders D) Leukocyte adhesion deficiency

A

B) Muscular dystrophy

56
Q

Which protein is critical for linking hemidesmosomes to laminin? A) Plectin B) α6β4 integrin C) BP230 D) Vinculin

A

B) α6β4 integrin

57
Q

What is the primary role of the plant cell wall in cell protection? A) Facilitates cell division B) Acts as an enclosure C) Promotes cell adhesion D) Inhibits transport

A

B) Acts as an enclosure

58
Q

Which integrin is associated with early embryonic death when the β1 subunit is mutated? A) α5β1 B) α6β4 C) αLβ2 D) αIIbβ3

59
Q

What is the primary component of the middle lamella in plant cell walls? A) Cellulose B) Pectin C) Hemicellulose D) Lignin

60
Q

Which structure in plasmodesmata regulates molecular transport? A) Desmotubule B) Cytoplasmic sleeve C) Plasma membrane D) Cellulose microfibril

A

B) Cytoplasmic sleeve

61
Q

What is the primary ligand for the αLβ2 integrin? A) Fibronectin B) Laminin C) ICAM1 D) Fibrinogen

62
Q

Which integrin is NOT involved in cell-matrix adhesion? A) α5β1 B) α6β4 C) αLβ2 D) α7β1

63
Q

What is the primary role of hemidesmosomes in skin epithelia? A) Cell communication B) Anchoring to basal lamina C) Barrier formation D) Electrical coupling

A

B) Anchoring to basal lamina

64
Q

Which component of the plant cell wall forms overlapping parallel arrays? A) Pectin B) Cellulose microfibrils C) Hemicellulose D) Glycoproteins

A

B) Cellulose microfibrils

65
Q

What is the primary function of the desmotubule in plasmodesmata? A) Provides tensile strength B) Connects endoplasmic reticulum C) Facilitates transport D) Cements cell walls

A

B) Connects endoplasmic reticulum

66
Q

Which integrin is associated with leukocyte adhesion deficiency? A) α5β1 B) αLβ2 C) α6β4 D) αIIbβ3

67
Q

What is the consequence of mutating the β4 subunit in the α6β4 integrin? A) Muscular dystrophy B) Skin blistering C) Bleeding disorders D) Leukocyte adhesion deficiency

A

B) Skin blistering

68
Q

Which protein is critical for integrin activation in platelets? A) Fibrinogen B) Thrombin C) ICAM1 D) Laminin

A

B) Thrombin

69
Q

What is the primary role of the plant cell wall in plant structure? A) Nutrient storage B) Skeletal support C) Cell communication D) Signal transduction

A

B) Skeletal support

70
Q

Which integrin is associated with Glanzmann disease? A) α5β1 B) α6β4 C) αIIbβ3 D) αLβ2

A

C) αIIbβ3

71
Q

What is the primary component of the cytoplasmic sleeve in plasmodesmata? A) Actin filaments B) Cytoplasm C) Cellulose D) Pectin

A

B) Cytoplasm

72
Q

Which protein is NOT involved in hemidesmosome formation? A) α6β4 integrin B) Plectin C) BP230 D) ZO-1

73
Q

What is the primary role of cellulose in the plant cell wall? A) Cell adhesion B) Tensile strength C) Nutrient transport D) Signal transduction

A

B) Tensile strength

74
Q

Which integrin is critical for myotendinous junctions? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

75
Q

What is the consequence of mutating the α5 subunit in the α5β1 integrin? A) Skin blistering B) Embryonic death C) Bleeding disorders D) Muscular dystrophy

A

B) Embryonic death

76
Q

Which component of the plant cell wall is involved in cross-linking? A) Cellulose B) Pectin C) Hemicellulose D) Lignin

77
Q

What is the primary function of plasmodesmata in molecular transport? A) Blocks all molecules B) Allows small molecule passage C) Transports proteins D) Inhibits ion flow

A

B) Allows small molecule passage

78
Q

Which integrin is associated with blood vessel defects when mutated? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

79
Q

What is the primary ligand for the α6β1 integrin? A) Fibronectin B) Laminin C) Fibrinogen D) ICAM1

A

B) Laminin

80
Q

Which protein is critical for linking hemidesmosomes to keratin filaments? A) Vinculin B) Plectin C) ZO-1 D) Plakoglobin

A

B) Plectin

81
Q

What is the primary role of the plant cell wall in fluid movement? A) Blocks fluid transport B) Provides channels for fluid C) Stores nutrients D) Inhibits cell growth

A

B) Provides channels for fluid

82
Q

Which integrin is NOT associated with laminin binding? A) α6β1 B) α7β1 C) α6β4 D) αLβ2

83
Q

What is the consequence of mutating the β2 subunit in the αLβ2 integrin? A) Skin blistering B) Leukocyte adhesion deficiency C) Bleeding disorders D) Muscular dystrophy

A

B) Leukocyte adhesion deficiency

84
Q

Which component of the plant cell wall is derived from glucose residues? A) Pectin B) Cellulose C) Hemicellulose D) Glycoproteins

A

B) Cellulose

85
Q

What is the primary function of the middle lamella in plant cells? A) Provides tensile strength B) Cements cell walls C) Regulates transport D) Supports plasma membrane

A

B) Cements cell walls

86
Q

Which integrin is associated with severe skin blistering when mutated? A) α5β1 B) α6β4 C) αLβ2 D) αIIbβ3

87
Q

What is the primary role of pectin polysaccharides in the plant cell wall? A) Provides tensile strength B) Cross-links microfibrils C) Cements adjacent cells D) Regulates transport

A

C) Cements adjacent cells

88
Q

Which structure in plasmodesmata is derived from the endoplasmic reticulum? A) Cytoplasmic sleeve B) Desmotubule C) Plasma membrane D) Cellulose microfibril

A

B) Desmotubule

89
Q

Which integrin is critical for fibronectin binding? A) α5β1 B) α6β4 C) αLβ2 D) αIIbβ3

90
Q

What is the primary function of hemidesmosomes in epithelial tissues? A) Cell communication B) Anchoring to basal lamina C) Barrier formation D) Electrical coupling

A

B) Anchoring to basal lamina

91
Q

Which component of the plant cell wall provides structural support? A) Pectin B) Cellulose microfibrils C) Hemicellulose D) Glycoproteins

A

B) Cellulose microfibrils

92
Q

What is the primary role of plasmodesmata in plant cells? A) Mechanical strength B) Cell communication C) Barrier formation D) ECM attachment

A

B) Cell communication

93
Q

Which integrin is associated with muscular dystrophy when mutated? A) α5β1 B) α6β1 C) α7β1 D) αLβ2

94
Q

What is the consequence of mutating the αL subunit in the αLβ2 integrin? A) Skin blistering B) Leukocyte adhesion deficiency C) Bleeding disorders D) Muscular dystrophy

A

B) Leukocyte adhesion deficiency

95
Q

Which protein is critical for hemidesmosome attachment to laminin? A) Plectin B) α6β4 integrin C) BP230 D) Vinculin

A

B) α6β4 integrin

96
Q

What is the primary role of the plant cell wall in cell enclosure? A) Facilitates cell division B) Acts as a protective barrier C) Promotes cell adhesion D) Inhibits transport

A

B) Acts as a protective barrier

Molecular Biology of the Cell (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions