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DOWNLOAD-D-11-53-5F0DB470BB61D Flashcards

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14 July 2020

A

sanjib.biology2012@gmail.com

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14 July 2020

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sanjib.biology2012@gmail.com

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3
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•

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Eg: Liver cells and Lymphocytes
Cells that normally possess a relatively high
level of mitotic activity.
Eg: stem cells of adult tissue

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4
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14 July 2020

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sanjib.biology2012@gmail.com

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5
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14 July 2020

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6
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14 July 2020

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7
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14 July 2020

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sanjib.biology2012@gmail.com

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8
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•Extracellular signals

A

(effect of growth factors

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9
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sanjib.biology2012@gmail.com

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10
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14 July 2020

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sanjib.biology2012@gmail.com

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11
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•if

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yeasts are faced with a shortage of

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12
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sanjib.biology2012@gmail.com

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13
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14 July 2020

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sanjib.biology2012@gmail.com

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14
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yeasts
passage of animal cells through the cell cycle
is regulated primarily by the extracellular
growth factors that signal cell proliferation,
rather than by the availability of nutrients

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15
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14 July 2020

A

sanjib.biology2012@gmail.com

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16
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point

A

in

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17
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14 July 2020

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18
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14 July 2020

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19
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14 July 2020

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20
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14 July 2020

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21
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•

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the cell cycle is regulated.They wanted to know whether the cytoplasm of cellscontains regulatory factors that affect cell cycleactivities.

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22
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14 July 2020

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23
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24
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14 July 2020

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sanjib.biology2012@gmail.com

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•
results suggested that
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•
cyclin D1 is also rapidly degraded, so its intracellular concentration rapidly falls if growth
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a
variety
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•
belongs to the Cip/Kip family. In addition, growth factor signaling via both the Ras/Raf/MEK/ERK and PI 3-kinase/ Akt pathways reduces the transcription and translation of p27, lowering the levels of p27 within the cell.
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The Licensing of DNA Replication in EukaryotesThe precise replication of DNA is accomplished by the separation ofthe initiation of replication into two distinct steps.
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operative in G1, S, and G2 phases of the cell cycle, serve to halt cell cycle progression and allow time for the damage to be repaired before DNA replication or cell division proceeds
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•Both
CHK1 and CHK2 phosphorylate and
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CHK2
phosphorylate
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of Cdk2At the G2 checkpoint, CHK1 and CHK2phosphorylate and inhibit Cdc25C, which isresponsible for activating Cdk1 I cyclin Bcomplexes.
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•This
increased
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•Activation of the APC is
induced at the beginning of mitosis, so the
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•The
Mad/Bub
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•The
presence of these proteins (especially Mad2) at an unattached
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oncology (1 decks)

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