Dosimetry equipment Flashcards

1
Q

List three ways to measure the energy deposited from ionising radiation.

A
  • Ionisation: collect ion pairs produced in air.
  • Calorimetry: ionising particle shares its energy with many others and eventually ions recombine. Energy ends up as heat.
  • Chemical effects: free radicals produced by ionising particles cause chemical changes.
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2
Q

What is the definition of exposure and what are the units?

A
  • “Total charge of ions (of one sign, so that we know how many ion pairs are produced)… in dry air when all electrons liberated in mass, δm, of air are completely utilised”.
  • Unit of Exposure is Charge liberated per unit mass [C/Kg]: i.e. photons interact with the medium to produce electrons. Those electrons deposit their kinetic energy by ionising the air and hence producing ion pairs in the air.
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3
Q

What are the complications with measuring exposure?

A
  • By definition, want to collect all ions produced by e-s in mass δm.
  • But e-s produced inside and outside δm.
  • Some ions produced by e-s travelling in are collected.
  • Some ions produced by e-s travelling out are lost.
  • Want electronic equilibrium to measure exposure.
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4
Q

What is electronic equilibrium and what are the dimensional conditions necessary to achieve this?

A
  • When no of ions produced by e-s travelling in is equal to no of ions produced by e-s travelling out.
  • To achieve electronic equilibrium: minimum dimension between boundaries of δm and surrounding interacting homogeneous medium must be > range of e-s.
  • The no of ion pairs collected = the same no as made by all interactions from e-s originating in the collecting volume.
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5
Q

Describe how a free-air ionisation chamber works and draw a diagram.

A
  • Photon beam passes between parallel plates (high polarising voltage, V).
  • X-rays produce electrons which cause ionisation.
  • Mass of air in collecting volume, δm, defined by guard plates and beam geometry.
  • Ions (not e-s) are collected and measured by circuitry.
  • V must be high enough to separate as many +ve and –ve ions before they recombine as possible (impossible to stop all recombination, but the remaining recombination can be quantified).
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6
Q

What radiation detector is used at the starting point of the calibration chain for KV x-ray dosimetry?

A
  • Free-air ionisation chamber.

- Used at the NPL.

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7
Q

What is a primary standard?

A
  • A Primary Standard makes an absolute measurement whereas secondary and other reference standard instruments must be calibrated.
  • A primary standard measures (or realises) the quantity of interest from first principles.
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8
Q

Give two examples of primary standards used at the NPL and which types of radiation they measure.

A
  • Free-air ionisation chamber (kV photons).

- Graphite calorimeters (MV photons & electrons).

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9
Q

What quantity does the free ionisation chamber measure and give an equation for this quantity.

A
  • KERMA.
  • i.e. the KE of the electrons produced by photons is used to make ions. These ions are collected.
  • KERMA = 33.97[eV]*C/em.
  • Since the ion chamber is in equilibrium, KERMA = DOSE (to air).
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10
Q

Describe how thimble ionisation chambers are calibrated at the NPL.

A
  • NPL KV beam air KERMA measured.
  • User thimble ionisation chambers are then irradiated in the same beam and a calibration factor derived for the user’s chamber.
  • Secondary standard measurement taken in a reference plane.
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11
Q

How do we convert from air KERMA to absorbed dose in water?

A
  • Dose to water = dose to air * ratio of mass-energy absorption coefficients for water/air (averaged over photon spectrum in air).
  • Dw,z=0 = (M)(Nk)(Bw)[(μen/ρ)w/air]air
  • M is reading from users thimble chamber.
  • Nk is air KERMA calibration factor.
  • Bw is backscatter factor (water).
  • [(μen/ρ)w/air]air is the ratio of mass-energy absorption coefficients for water/air.
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12
Q

State the differences between a free-air chamber and a thimble chamber.

A
  • Free-air chamber:
  • Small air cavity, δm + surrounding air volume (dimensions > R).
  • Thimble chamber:
  • Replace air shell with a solid shell of equivalent Z (e.g. graphite).
  • Small air cavity + surrounding air-equivalent wall (dimensions > R).
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13
Q

Describe the design of a thimble ionisation chamber and draw a diagram.

A
  • Ionisation chamber encloses a small volume of air in thimble-like conducting (graphite) cap with an insulated axial collecting electrode.
  • Walls are material with similar atomic number to air, Zair.
  • Wall thickness > R in wall (1mm wall = 1m air).
  • Can then measure exposure without free-air chamber.
  • Dose is proportional to exposure, so these chambers can be calibrated against primary dosimetry standards and used for hospital measurements.
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14
Q

Describe how a thimble chamber measures charge.

A
  • High polarising voltage between the wall and the central electrode (200V cm-1 gap for saturation).
  • Ions produced in the cavity move to one or the other electrode.
  • Collected charge is measured using an Electrometer (basically an op-amp).
  • Volume is typically 0.6ml.
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15
Q

State the differences between large and small ionisation chambers.

A
  • Large chambers:
  • Very sensitive, but low spatial resolution.
  • Used for environmental monitoring.
  • Small chambers:
  • Good spatial resolution, but small signal.
  • Used for fine resolution scanning.
  • 0.6 cubic centimeter “Farmer” chamber is the most commonly used chamber for photons in Radiotherapy Physics.
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16
Q

What are parallel plate chambers used for and what are the advantages of using them?

A
  • Sometimes measure in high dose gradient fields.
  • e.g. electron beams, KV beams, build-up region of MV beams.
  • Thin in direction of gradient for better resolution.
  • Detecting volume still large enough for decent signal.
  • Thimble chambers too big to use here, will get contribution from other parts of high gradient field.
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17
Q

Describe how a calorimeter works and give an approximate value for the temperature increase from 1Gy.

A
  • Absorbed dose = Energy/mass.
  • E=mcΔT, therefore:
  • Dose = cΔT -> direct measurement of absorbed dose.
  • NPL uses graphite calorimeters as Primary Standard (MV & Electrons) and converts to water using ratio of electron densities (photon fluence scaling theorem).
  • Water difficult to use directly since it has a large specific heat capacity and difficulties with purity.
  • 1Gy produces a ΔT of about 1.5mK in a graphite calorimeter (0.24mK in water).
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18
Q

What methods for graphite calorimetry are required to obtain a measurement with acceptable precision?

A
  • Need method capable of measuring ΔT = 10^-6K.
  • Isolating the core thermally (vacuum).
  • Rather than allowing the temperature to rise and attempting to measure it, the NPL have a more accurate method were they keep the temperature constant by reducing the current in a heating circuit in the calorimeter to stop the temperature rising when the radiation beam is turned on. They measure the change in electrical power in their heating circuit and use this to calculate:
  • Dose to graphite core = change in (Volts x Amps) x Time beam is on / Mass of graphite core.
  • i.e. Dose = (ΔPower*time)/(mass).
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19
Q

Describe the structure of a graphite calorimeter and draw a diagram.

A
  • Inner graphite core (volume where temperature rise is to be determined).
  • Core surrounded by two graphite ‘jackets’ which together present an ~ homogenous graphite phantom.
  • Core thermally isolated from outer jackets by a vacuum.
  • Temperature rise in core measured using highly sensitive thermistors and converted to dose to graphite.
  • The design (jackets) allows the calorimeter to be used in an adiabatic mode i.e. without heat transfer (Dose to graphite core = change in (Volts x Amps) x Time beam is on / Mass of graphite core).
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20
Q

Describe how NPL reference chambers and user secondary standard chambers are calibrated at the NPL.

A
  • NPL reference chambers:
  • Calibrated against calorimeter at different beam qualities.
  • Calibration converted from graphite to water using Monte Carlo simulations, measurements and photon fluence scaling theorem.
  • User secondary standard chambers:
  • Calibrated against NPL reference chambers.
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21
Q

What is a secondary standard chamber and what is the procedure for calibration?

A
  • High quality dosemeters owned by Hospitals.
  • The secondary standards are sent to NPL to be calibrated against the NPL primary standard (kV photons) or, in the case of MV photons, against the NPL reference chambers (where the NPL reference chambers are calibrated against the primary standard calorimeter).
  • NPL provides a correction factor to convert dose readings made with the secondary standard into accurate dose measurements.
  • This calibration transferred to field instruments via cross-calibration.
  • Field instruments used for routine dosimetry.
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22
Q

Describe the method for calibrating field instruments.

A
  • Field instrument and secondary standard are placed side by side in a large Perspex phantom at a fixed depth and irradiated.
  • By irradiating simultaneously at same depth can ensure that they get the same dose.
  • Ratio of readings from field instrument and secondary standard taken.
  • Repeated twelve times with position of each chamber swapped after each three times and average ratio determined.
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23
Q

What is the quality dependent factor and how can it be obtained?

A
  • Due to chamber construction, response varies with beam energy spectrum.
  • The energy spectrum is quantified by a single number that is referred to as a measure of the beam “quality”.
  • The measure of beam quality is the TPR20/10.
  • [TPR20/10 is the “Tissue Phantom Ratio” of 20cm reading / 10cm reading. i.e. a ratio of ionisation chamber readings when measured at 2 different depths, everything else kept constant].
  • The hospital’s secondary standard chamber is calibrated against the NPL reference chamber (which itself was calibrated against the primary standard calorimeter) at a number of different TPR 20/10 values (quality indices), and a calibration curve produced for the secondary standard chamber.
  • ND varies by about 4% across beam qualities for MV photons.
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24
Q

What is the quality index (QI) used in MV photon dosimetry? Draw a diagram showing how QI is measured.

A
  • TPR20/10 ratio.

- QI = R20/R10.

25
Q

What is the relation between dose to water (Dw) and reading (M) on the secondary standard? Explain the need for correction factors.

A
  • Dw = MND(Q)ftpfionNelec*fnon-lin.
  • ND(Q) only valid for specific set up conditions (standard temp & pressure, zero ion recombination, correcting for charge calibration of the electrometer scale, correcting for any non-linearity of the electrometer scale).
  • Therefore correction factors needed to account for set up conditions.
26
Q

Explain why a temperature and pressure correction is required when measuring phantom dose (MV photons) and give the correction factor.

A
  • Charge α mass of air in chamber.
  • From gas laws:
  • Increase in P, mass of gas in chamber will increase.
  • Increase in T, mass of gas in chamber decreases.
  • (1013.25)/(P)*(273.15+T)/(293.15). [p in milliBar, T in °C].
27
Q

Explain what ion recombination is and draw a graph of I vs V for three different exposure rates.

A
  • If voltage is not high enough, the measured charge will be proportional to voltage.
  • At a particular saturation voltage (Vsat) the current is saturated for a given exposure rate. i.e. (nearly) all ions formed are collected.
  • All ionisation chambers must operate under saturation conditions if their response is to be linear with exposure.
  • At low exposure rates “initial” recombination occurs, which is recombination of ion pairs within a given track. This is independent of exposure rate. At high exposure rates there can be interaction between ionisation tracks (known as “general” recombination) which is a function of exposure rate.
  • Hence if the current is not saturated then at high exposure rates the current collected = a number which varies with exposure rate x exposure rate.
  • We do not want the current we collect with our ionsation chambers to be non-linear with exposure rate.
  • Once the current is saturated then the current collected will be a constant multiple of the exposure rate.
28
Q

Why is an ion recombination correction required when measuring phantom dose (MV photons) and how does ion recombination vary between different operating voltages?

A
  • Not all the charge liberated in the ionisation chamber is collected.
  • Some ion pairs recombine. (About 0.5%).
  • Increased recombination at lower operating voltages and linacs operating with higher dose per pulse.
  • This can be quantified by measuring the charge collected at different polarising voltages.
29
Q

State the equations for the calibration of a field instrument from a secondary standard.

A
  • Dw,field = Dw,std = MstdND,W,std(Q).fTPfion,stdNelec,stdfnonlin,std.
  • Dw,field = MfieldMstd/MfieldND,W,std(Q)fTPfion,stdNelec,stdfnonlin,std.
  • Let ND,w,field(Q) = Mstd/MfieldND,W,std(Q)fTPfion,stdNelec,std*fnonlin,std.
  • => Dw,field = MfieldND,w,field(Q)fTP*fion,field/fion,field,xcal conditions.
  • If pulse size (and hence fion) doesn’t change significantly under different measurement conditions then:
  • Dw,field = MfieldND,w,field(Q)fTP.
30
Q

What are the corrections that need to be applied to a chamber measurement to obtain the actual charge?

A

-Actual charge = Displayed charge * Nelec*fnonlin.

31
Q

Describe the calibration chain for electron secondary standard.

A
  • Chambers are calibrated in water at NPL against 3 reference NACP chambers that the NPL keep.
  • First though the reference chambers are calibrated in graphite against the electron primary standard graphite calorimeter.
32
Q

Describe and summarise the calibration chain.

A
  • All dose measurements traceable back to national standard held at the NPL.
  • Ensures accurate dosimetry.
  • Ensures consistent dosimetry between centres.
  • Primary radiation standard (calorimeter of free-air chamber), NPL.
  • Secondary standard dosemeter, regional centre.
  • Field instruments (e.g. farmer dosemeters)
  • Dose checker, TLD, in vivo diodes.
33
Q

List some desirable radiation detector properties.

A
  • Accurate.
  • Sensitive.
  • Linear response.
  • Independent of dose rate and energy.
  • Reading converts readily to dose in tissue.
  • Appropriate spatial resolution.
34
Q

State the differences between ion chambers and solid state diodes when measuring absolute dose.

A
  • Ion chamber:
  • Densities and effective atomic number Zeff close to water therefore only minor perturbation of energy fluence.
  • Solid state diode:
  • Higher density and Z (~28) than water leads to significant perturbation of energy fluence.
  • Over-response to lower energy components.
35
Q

State the differences between ion chambers and solid state diodes when measuring PDD.

A
  • Ion chamber:
  • Ideal as near flat energy response.
  • Solid state diode:
  • High resolution of very small active volume useful (particularly in build-up region) but response varies with energy.
36
Q

State the differences between ion chambers and solid state diodes when measuring output factors.

A
  • Ion chamber:
  • Spectral variation over wide range of field sizes not an issue.
  • Physical size of collecting volume may be an issue at smaller field sizes (<4x4cm, loss of lateral electronic equilibrium).
  • Smaller volumes leads to reduced sensitivity.
  • Solid state diode:
  • Size of active component makes measurement of small fields feasible.
  • Retained sensitivity in small fields.
  • Variation of energy spectrum may be sufficiently small to ignore over small range of field sizes.
37
Q

State the differences between ion chambers and solid state diodes when measuring penumbra (beam profile).

A
  • Ion chamber:
  • Acceptable but low resolution due to ‘large’ collecting volume.
  • Pin-point and micro chambers improve resolution but less sensitive.
  • Solid state diode:
  • Steep dose gradients require high resolution for accurate spatial distribution.
38
Q

Describe the principle of thermoluminescence.

A
  • Lattice impurities within crystal produce additional energy levels just a few eV below conduction band.
  • Meta-stable states can ‘trap’ electrons.
  • Radiation excites electrons to conduction band.
  • Electrons relax back to valence band but some get trapped.
  • Heating material results in trapped electrons returning to conduction band and then relaxing to valence band, emitting light.
  • Light collected α absorbed dose.
39
Q

State the advantages and disadvantages of using TLDs.

A
  • Advantages:
  • Linear response with dose over wide range (~0.001 to ~10Gy).
  • Sensitivity is almost energy independent (MV range).
  • Small size (chips ~2mm) provides high resolution.
  • No leads / connections required.
  • Disadvantages:
  • Must be calibrated.
  • ‘Fade’ with time after irradiation (typically ≤10%/year).
  • Careful annealing is required between uses to ensure TLD returns to the original condition (w.r.t e- traps).
  • Affected by previous thermal & radiation history.
  • Reader constancy difficult to maintain over long periods.
40
Q

Describe the method for reading a LiF TLD.

A
  • ‘Settling’ period required post irradiation (~12-24 hours).
  • Placed in TLD reader:
  • Heated to 300°C at controlled rate.
  • Measure light emitted during heating (glow curve).
  • Anneal cycle involves:
  • 1 hour at 400°C.
  • 12 hours at 80°C.
  • 24 hours cooling to ambient temperature.
41
Q

List the uses for TLDs in radiotherapy.

A

-Commissioning and QA:
-Small fields.
-Surface dose/high dose gradients.
-SXT backscatter.
-Internal dose (phantoms).
-Patient dosimetry:
-Total Body Irradiation (TBI).
-Total Skin Electron Irradiation (TSEI).
-Eye dose estimates.
-Personal dosimetry:
-Multi-chip badges.
Single chip finger holders.

42
Q

Describe how total body irradiation (TBI) is measured using TLDs.

A
  • Patient setups assessed during ‘Test Dose’.
  • TLD sachets situated on both sides of patient at several locations along length of body.
  • Additional TLD sachets irradiated at known doses to produce calibration curve.
  • Results compared to expected mid-line dose.
  • Achievable accuracy of +-5% at 95% confidence.
43
Q

State the advantages and disadvantages of using film dosimetry.

A
  • Advantages:
  • Good spatial resolution (grains < 100 μm). But limited in practice by aperture size of scanner.
  • Convenient for aspects of Linac commissioning & QC
    e. g. star shots, light / radiation coincidence.
  • Can be calibrated for absolute dose measurement, but caution required though.
  • Geometry well-suited for dose mapping - thin, flat, large area.
  • Disadvantages:
  • Silver halide film requires wet processing - needs to be well-controlled and consistent (and be available!).
  • Silver halide film sensitivity is energy dependent - ‘high’ Z - preferential absorption of photons ≤150kV (PE α Z^3).
  • Radiochromic: dose sensitive to scan parameters (active layer uniformity, orientation).
44
Q

Describe the features of radiographic film and draw a diagram.

A
  • Supercoat protects emulsion against physical damage.
  • Clear polyester base provides rigidity.
  • Base thickness minimised to reduce impact on resolution.
  • Layer(s) of gelatine emulsion contain Ag Halide crystals.
  • Halide composition:
  • ~90% AgBr.
  • ~10% AgI or AgCl.
  • Grains ~0.1-3 μm.
  • 10^9-10^12 grains cm^-2.
45
Q

Explain how radiographic film is used to measure dose.

A
  • Development leaves opaque microscopic grains of silver.
  • Grains detected optically & quantity related to dose.
  • Large grains (fast film) requires less radiation but gives lower resolution.
  • Optical density vs. dose gives the ‘Characteristic Curve’.
  • Calibration curve required for absolute dosimetry.
46
Q

State some advantages of using radiochromic film (GafC).

A
  • Self-developing - films are scanned i.e. no processor or darkroom required.
  • Rapid assessment of non-dosimetric investigations.
  • Sensitivity is virtually independent of photon energy.
  • Tissue equivalent.
  • Can immerse in water.
  • More expensive (~£20/sheet), but no processing costs.
  • Can be cut to any size or shape for efficiency.
47
Q

How does radiochromic film work and how does the dose response compare to that of radiographic film?

A
  • Exposure causes reactions between polymers: original transparent layer becomes opaque α absorbed dose.
  • Dose response is ~0.25 x Ag Halide film.
48
Q

Describe the active layer in radiographic film.

A
  • Composed of 2-15μm ‘rods’ (scan orientation important).
  • Rod alignment parallel to overlaminate coating direction.
  • Incorporates yellow dye to enable inhomogeneity corrections.
49
Q

Why is the red channel used for dosimetry when scanning radiochromic film with an RGB film scanner?

A
  • Red channel displays greatest response gradient.

- Response gradient = change in response per unit change in dose.

50
Q

Describe the method for scanning radiochromic film after exposure.

A
  • Films must be scanned in the same orientation as those used to produce the calibration file - landscape recommended for single channel dosimetry or either orientation for multi-channel.
  • Post exposure, optical Density growth α log(time after exposure).
  • Scan after ~1-2 hours for consistency.
  • Delay has minimal impact on dosimetric accuracy.
51
Q

how can film dosimetry be used in commissioning and QA?

A
  • Linac:
  • Gantry/collimator ‘Star Shots’ -assessment of isocentric setup.
  • PDD - assessment of shallowest depths.
  • Light vs. radiation field size - routine MLC/Jaw QA.
  • ‘Picket fence’ testing - MLC QA.
  • HDR applicator:
  • Radiographs - dimensional analysis.
  • Autoradiographs - source positioning.
  • Superficial x-ray therapy (SXT):
  • Focal spot size.
  • Applicator size.
  • Beam uniformity.
52
Q

how can film dosimetry be used to assess patient dosimetry?

A
  • Complex distributions:
  • IMRT.
  • Tomotherapy.
  • Scanning permits:
  • 1-D profile assessments.
  • 2-D dose difference.
  • 2-D gamma analysis.
53
Q

Explain how chemical dosimetry works.

A
  • The absorption of ionising radiation in a material results in a cascade of secondary electrons. These, in turn, transfer energy to molecules, resulting in ionisation, excitation and the breaking of chemical bonds.
  • Many radiation induced chemical species are extremely reactive, but often lead to relatively stable products. The detection of these stable products is the basis of chemical methods of dosimetry.
54
Q

Explain how Fricke solutions/gels can measure dose.

A
  • Radiation oxidises 4% ferrous sulphate solution (water constitutes remaining 96%) to ferric sulphate.
    i. e. Fe2+ -> Fe3+.
  • Fe2+/Fe3+ ratio measured by absorption spectrophotometry.
  • Change α absorbed dose.
55
Q

What are Fricke solutions/gels useful for? List some current developments.

A
  • Useful as an independent check of calibration procedures.
  • NPL runs a Fricke dosimetry service.
  • Current developments include Fricke Gels:
  • Spatial position of Fe3+ following irradiation is fixed in a gel.
  • Spatial distribution ‘read out’ using MRI.
  • [Difficulties with toxic ‘ingredients’ and consistent preparation.]
56
Q

Explain how Alanine is used to measure dose.

A
  • Solid-state cylindrical pellets (5mm diameter x 2.5mm thick).
  • Near tissue equivalent (CH3CH(NH2)COOH), density ~1.2g cm-3.
  • Low energy dependence.
  • Irradiation produces long-lived free radical species.
  • Absorbed dose determined via X-band (~9GHz) electron paramagnetic resonance (EPR) spectrum of free radicals.
57
Q

State the advantages and disadvantages of using Alanine.

A
  • Advantages:
  • Can use multiple pellets (improved statistics).
  • Measurement precision better than ±1% (1σ) for 5-10Gy.
  • Can compare to secondary standard.
  • Disadvantages:
  • Corrections required:
  • Conversion factor (~1.006) applied to get ‘dose-to-water’.
  • Temperature corrections (+-1.5% dose with +-10°C).
58
Q

State the uses for both Ficke solution/gels and alanine.

A
  • Fricke Solutions/Gels:
  • Departmental or national audit (service offered by NPL).
  • Low energy electron beam and Ir-192 dosimetry.
  • 3-D dose distribution visualisation.
  • Alanine:
  • Departmental or national audit (service offered by NPL).
  • Linac commissioning (e.g. Tomotherapy).
  • Individual patient dosimetry (e.g. small IMRT segments).