dosage form design I & II Flashcards

1
Q

How do dosage forms help patient acceptability?

A

By improving

  • taste
  • appearance
  • stability
  • availability
  • absorption
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2
Q

Define dosage form

A

The clinical pakage in which a drug is presented to a patient.

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3
Q

What is the aim of dosage form designs? What does this involve?

A

To convert an active drug into a form that is stable, reliable, convenient, palatable and effective.
This involves the physical form of the product, physico-chemical properties of the drug and excipients, control of maintenance at the target site and rate of drug release, the method of manufacturing and ROAs

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4
Q

What are features of a successful dosage form?

A
  • chemical and physical stability
  • suitable preservation
  • content uniformity
  • acceptibility to user and doctor
  • suitable packaging and labelling
  • devoid of patient variability (ideally)
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5
Q

How must a drug behave to be bioavailable?

A
  • released completely from dosage form
  • fully dissolved in body fluids
  • stablein fluids in a solution form
  • pass through mucosal barrier into bloodstream without being metabolised.
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6
Q

What factors effect our choice of dosage form?

A
  • biopharmaceutical parameters of the drug
  • physical and chemical properties of the drug
  • therapeutic factors
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7
Q

What biopharmaceutical factors effect dosage form choice?

A

ADME

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8
Q

What physico-chemical properties affect dosage form choice?

A

particle size, solubility, dissolution, partition coefficient, stability, crystal properties, organoleptic properties.

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