dosage form design I & II

Question 1

How do dosage forms help patient acceptability?

Answer 1

By improving

• taste
• appearance
• stability
• availability
• absorption

Question 2

Define dosage form

Answer 2

The clinical pakage in which a drug is presented to a patient.

Question 3

What is the aim of dosage form designs? What does this involve?

Answer 3

To convert an active drug into a form that is stable, reliable, convenient, palatable and effective.
This involves the physical form of the product, physico-chemical properties of the drug and excipients, control of maintenance at the target site and rate of drug release, the method of manufacturing and ROAs

Question 4

What are features of a successful dosage form?

Answer 4

• chemical and physical stability
• suitable preservation
• content uniformity
• acceptibility to user and doctor
• suitable packaging and labelling
• devoid of patient variability (ideally)

Question 5

How must a drug behave to be bioavailable?

Answer 5

• released completely from dosage form
• fully dissolved in body fluids
• stablein fluids in a solution form
• pass through mucosal barrier into bloodstream without being metabolised.

Question 6

What factors effect our choice of dosage form?

Answer 6

• biopharmaceutical parameters of the drug
• physical and chemical properties of the drug
• therapeutic factors

Question 7

What biopharmaceutical factors effect dosage form choice?

Answer 7

ADME

Question 8

What physico-chemical properties affect dosage form choice?

Answer 8

particle size, solubility, dissolution, partition coefficient, stability, crystal properties, organoleptic properties.