Dosage Effects and Drug Response Curves, Effective/Toxic/Lethal Dose, Drug Design Flashcards
What is a dose-response relationship?
Relationship between the amount of drug and the magnitude of the effect the drug produces
often affected by body weight, doses given in mg drug/kg body weight
What does an individual dose response curve tell us?
group-dose response curve?
individual: effect of a drug on a person (potency)
group: the number of individuals that have the desired effect over a range of doses
What is Effective Dose?
What is Toxic Dose?
What is Lethal Dose?
What is Therapeutic Index?
What is Therapeutic Window?
How is TI calculated in animals and humans?
What is the ideal relationship between ED and TD/LD?
ED: dose of drug that produces the desired effect in a given percentage
ex) ED1 is the dose that produces effect in 1% of the population
TD: dose of drug that results in medically unacceptable adverse effects
LD: dose of drug that causes death (only in animals)
TI: ratio to determine how close toxic/lethal dose is to an effective one
TW: range of dose that is still safe, NO/MIN ADVERSE EFFECTS
TI animals: LD50/ED50
TI humans: TD50/ED50
ideal: low ED, high TD/LD
What is rational drug design?
research focuses on identifying a suitable molecular target in the body, and designing a drug to interact with it
