Dosage Calc Module Flashcards
What is the Henderson-Hasselbalch Equation used to calculate?
- how the pH of a solution effects acids in solution
- where in the body an acidic drug will be absorbed
T/F: pKa represents the strength of an acid
- TRUE
- pH at which the concentration of the ionized form is equal to the concentration of the non-ionized
Define loading dose
dose administered to primer the bloodstream with a plasma drug level sufficient to quickly induce a therapeutic effect
T/F: clearance is defined as the volume of plasma completely cleared of a drug per per gram of drug. (if F, correct)
- F
- per unit time
What assumptions does clearance of a drug make about the individual?
-assumes proper functioning of kidney and liver
Define maintenance dose
-dose of drug administered intermittently to keep plasma drug concentrations within the therapeutic range
What does variable W(d) mean?
weight of drug (dose) administered
What does variable [D]o mean? (2)
- top of therapeutic range or
- concentration of a drug (in the plasma) at the start of measurement
What does variable V(d) mean?
apparent volume of distribution (volume into which a drug distributes throughout the body)
What does variable K mean?
elimination rate constant
What does variable T1/2 mean?
half life; amount of time during which the concentration of a drug decreases by 50%
What does variable [D]pl mean?
middle of therapeutic range
What does variable T mean?
dose interval (time between doses)
What does variable [D] mean? (2)
- bottom of therapeutic range
or
-concentration of a drug in the plasma at the end of a given time
What is the equation always used to find the elimination rate constant
k=0.693/half life (T 1/2)
