Dopamine pathway

Question 1

dopamine - nigrostriatal pathway

Answer 1

Origin: substantia nigra
Projection: basal ganglia
Effects: motor

Question 2

dopamine - mesolimbic pathway

Answer 2

Origin: ventral tegmentum
Projection: nucleus accumbens
Effects: rewards, delusion, hallucinations (positive schizophrenia symptoms)

Question 3

dopamine - mesocortical

Answer 3

Origin: ventral tegmentum
Projection: frontal and pre-frontal cortex
Effects: cognitive symptoms (inattention, impaired memory, executive function) and negative symptoms, eg. anhedonia (table 50-3 Dipiro)

Question 4

dopamine - tuberoinfundibular

Answer 4

Origin: hypothalamus
Projection: pituitary gland
Effects: hyperprolactinemia