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PDA EXAM 3 > Dopamine and more > Flashcards

Dopamine and more Flashcards

1
Q

Metirosine

A

inhibition of biosynthesis, TYROSINE hydroxylase (TH), hypertension, (dopamine, adrenergic)

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2
Q

Carbidopa

A

Inhibition of biosynthesis, DOPA decarboxylase (DDC), parkinsons (dopamine, adrenergic)

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3
Q

Reserpine

A

inhibition of storage, Vesicular monoamine transporter 1&2 (VMAT 1&2), Hypertension (dopamine)
JUST VMAT FOR ADRENERGIC

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4
Q

tetrabenazine

A

inhibition of storage, VMAT2, chorea. (dopamine)

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5
Q

Altropane

A

inhibition of reuptake , dopamine transporter (DAT), attention deficit hyperactivity disorder(ADHD). DOPAMINE.

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6
Q

Entacapone

A

inhibition of degradation, COMT, parkinsons (dopamine, adrenergic)

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7
Q

Selegiline

A

inhibition of degradation, MAO, antidepressant. (dopamine, adrenergic)

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8
Q

Parkinsons disease
Hyperprolactinemia
Restless Leg Syndrome

A

decrease in Dopamine

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9
Q

What are the two dopamine agonists?

A

ergoline and non-ergoline

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10
Q

Schizophrenia
Bipolar disorder
Huntingtons disease

A

increased dopamine function

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11
Q

Dopamine receptor antagonists

A

first generation antipsychotics
second generation antipsychotics.

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12
Q

cabergoline and bromocriptine

A

dopamine receptor ergoline agonist, D2- like receptors, hyperprolactinemia.

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13
Q

Pramipexole and Rotigotine

A

dopamine reeceptor agonist non-ergoline type, D2-like receptors, parkinsons disease and restless leg syndrome.

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14
Q

Fluphenazine

A

dopamine receptor antagonist first generation, D2 like receptor, Huntingtons disease.

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15
Q

Risperidone & Olanzapine

A

dopamine receptor antagonist second generation, schizophrenia and bipolar disorder.

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16
Q

Haloperidol

A

dopamine receptor antagonist second generation, Schizophrenia and bipolar disorder AND huntington disease.

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17
Q

Low levels of adrenergic Neurotransmitter. low levels of norepinephrine and epinephrine

A

ADHD

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18
Q

Guanethidine

A

inhibition of release, fusion process, hypertension (adrenergic)

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19
Q

bretylium

A

inhibition of release, fusion process, arrhythmic (adrenergic)

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20
Q

cocaine

A

inhibition of reuptake, Norepinephrine Transporter (NET), Pain management

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21
Q

Tricyclic antidepressants

A

Norepinephrine transporter (NET), antidepressant.

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22
Q

What does the a1 adrenergic receptor do?

A

Gaq
phospholipase C
IP3 and DAG
Ca2+
PKC
ACTIVATESSSSS
really diff than the others

23
Q

what does the a2 adrenergic receptor do?

A

Gai
AC
cAMP
PKA
ONLY ONE THAT INHIBITS

24
Q

what does the b1, b2, and b3 adrenergic receptor do?

A

Gas
AC
cAMP
PKA
all beta adrenergic receptors activate the same.

25
Q

What are Direct-acting non selective Adrenergic agonists?

A

epinephrine (a1,a2,b1,b2) and norepinephrine (a1,a2,b1), and isoprenaline (b1,b2)

26
Q

What are Indirect-acting MAO inhibitors?

A

selegiline

27
Q

What are indirect-acting COMT inhibitors?

A

entacapone

28
Q

What is a mixed acting adrenergic agonist?

A

ephedrine (a1,a2,b1,b2,and releasing agent)

29
Q

Epinephrine (direct-Acting Non selective Agonist)

A

heart problems
Epi pen
Asthma
prolong anesthetic

30
Q

norepinephrine (Direct-Acting Non selective agonist)

A

hypotension (low blood pressure)
vasodilatory shock- septic shock and neurogenic shock

31
Q

Isoprenaline (Direct- Acting Non selective agonist)

A

Emergency for cardiac arrest, hypovolemic shock, septic shock.
congestive heart failure
asthma

32
Q

Phenylephrine (direct-Acting selective a1 agonist)

A

hemorrhoids and
Vasopressor: increase in blood pressure

33
Q

Clonidine (direct-acting selective a2 agonist)

A

hypertension: lower blood pressure
IBS
psychiatric disorders

34
Q

Dobutamine (Direct-Acting selective b1 Agonist)

A

increase contractility
cardiac output

35
Q

Albuterol (direct acting selective b2 Agonist)

A

less ca2+ resulting in less muscle contraction.
allergic asthma
rescue inhaler
chronic obstructive pulmonary disease

36
Q

Mixed Acting Non-selective Agonist: Ephedrine

A

raises systolic and diastolic blood pressure by vasoconstriction and cardiac stimulation
Hypotension
asthma
enhancement on sleep
decrease motion sickness

37
Q

what are the three types of antagonists on adrenergic receptors?

A

a receptor antagonist, b receptor antagonist, a &b receptor antagonist.

38
Q

phenyoxybenzamine

A

nonselective a receptor blocker of a1 and a2.
hypertension

39
Q

-zosin ANYTHING ENDING IN ZOSIN

A

selective a1 receptor blocker for adrenergic receptor. on exam

40
Q

this is a a1 blocker, is a first choice for patients with both hypertension and prostatic hyperplasia.

A

prazosin. said is gonna be on the exam

41
Q

What are the b Blockers of adrenergic receptors known as? all of them end in olol

A

THE GENERATIONS.
first gen
second gen- b1 selective
third gen- nonselective and b1 selective

42
Q

1st gen non selective drugs

A

Propanolol (POPSTNolol)
Oxprenolol
Pindolol
Sotalol
Timolol
Nadolol

43
Q

2nd gen b1- selective drugs

A

metoprolol (maabeolol2)
acebutolol
atenolol
Bisoprolol
Esmolol

44
Q

3rd gen nonselective

A

CCL
Carteolol
Carvedilol- also block a1
Labetalol- also block a1

45
Q

3rd gen b1-selective

A

BN
Betaxolol
Nebivolol

46
Q

what is the only a2 selective antagonist on adrenergic a receptors.

A

Yohimbine

47
Q

metoprolol

A

2nd gen beta blocker
blocks the action of epinephrine and norepinephrine at b1 adrenergic receptor.

48
Q

Paroxetine, Fluoxetine, Sertraline

A

SSRI, Serotonin Transport, Depression

49
Q

Desvenlafaxine

A

SNRI, serotonin or norepinephrine transporter, Depression

50
Q

Venlafaxine and Duloxetine

A

SNRI, serotonin or norepinephrine transporter, depression AND anxiety

51
Q

Levomilnacipran

A

SNRI, serotonin or norepinephrine transporter, depression

52
Q

Phenelzine

A

MAOI, monoamine oxidase, depression and anxiety

53
Q

Cyproheptadine

A

Antagonist, 5-HT2 receptor. Serotonin syndrome

54
Q

What is the only thing that is synthesized by tryptophan

A

serotonin.

PDA EXAM 3 (2 decks)

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