Dopamine and more

Question 1

Metirosine

Answer 1

inhibition of biosynthesis, TYROSINE hydroxylase (TH), hypertension, (dopamine, adrenergic)

Question 2

Carbidopa

Answer 2

Inhibition of biosynthesis, DOPA decarboxylase (DDC), parkinsons (dopamine, adrenergic)

Question 3

Reserpine

Answer 3

inhibition of storage, Vesicular monoamine transporter 1&2 (VMAT 1&2), Hypertension (dopamine)
JUST VMAT FOR ADRENERGIC

Question 4

tetrabenazine

Answer 4

inhibition of storage, VMAT2, chorea. (dopamine)

Question 5

Altropane

Answer 5

inhibition of reuptake , dopamine transporter (DAT), attention deficit hyperactivity disorder(ADHD). DOPAMINE.

Question 6

Entacapone

Answer 6

inhibition of degradation, COMT, parkinsons (dopamine, adrenergic)

Question 7

Selegiline

Answer 7

inhibition of degradation, MAO, antidepressant. (dopamine, adrenergic)

Question 8

Parkinsons disease
Hyperprolactinemia
Restless Leg Syndrome

Answer 8

decrease in Dopamine

Question 9

What are the two dopamine agonists?

Answer 9

ergoline and non-ergoline

Question 10

Schizophrenia
Bipolar disorder
Huntingtons disease

Answer 10

increased dopamine function

Question 11

Dopamine receptor antagonists

Answer 11

first generation antipsychotics
second generation antipsychotics.

Question 12

cabergoline and bromocriptine

Answer 12

dopamine receptor ergoline agonist, D2- like receptors, hyperprolactinemia.

Question 13

Pramipexole and Rotigotine

Answer 13

dopamine reeceptor agonist non-ergoline type, D2-like receptors, parkinsons disease and restless leg syndrome.

Question 14

Fluphenazine

Answer 14

dopamine receptor antagonist first generation, D2 like receptor, Huntingtons disease.

Question 15

Risperidone & Olanzapine

Answer 15

dopamine receptor antagonist second generation, schizophrenia and bipolar disorder.

Question 16

Haloperidol

Answer 16

dopamine receptor antagonist second generation, Schizophrenia and bipolar disorder AND huntington disease.

Question 17

Low levels of adrenergic Neurotransmitter. low levels of norepinephrine and epinephrine

Answer 17

ADHD

Question 18

Guanethidine

Answer 18

inhibition of release, fusion process, hypertension (adrenergic)

Question 19

bretylium

Answer 19

inhibition of release, fusion process, arrhythmic (adrenergic)

Question 20

cocaine

Answer 20

inhibition of reuptake, Norepinephrine Transporter (NET), Pain management

Question 21

Tricyclic antidepressants

Answer 21

Norepinephrine transporter (NET), antidepressant.

Question 22

What does the a1 adrenergic receptor do?

Answer 22

Gaq
phospholipase C
IP3 and DAG
Ca2+
PKC
ACTIVATESSSSS
really diff than the others

Question 23

what does the a2 adrenergic receptor do?

Answer 23

Gai
AC
cAMP
PKA
ONLY ONE THAT INHIBITS

Question 24

what does the b1, b2, and b3 adrenergic receptor do?

Answer 24

Gas
AC
cAMP
PKA
all beta adrenergic receptors activate the same.

Question 25

What are Direct-acting non selective Adrenergic agonists?

Answer 25

epinephrine (a1,a2,b1,b2) and norepinephrine (a1,a2,b1), and isoprenaline (b1,b2)

Question 26

What are Indirect-acting MAO inhibitors?

Answer 26

selegiline

Question 27

What are indirect-acting COMT inhibitors?

Answer 27

entacapone

Question 28

What is a mixed acting adrenergic agonist?

Answer 28

ephedrine (a1,a2,b1,b2,and releasing agent)

Question 29

Epinephrine (direct-Acting Non selective Agonist)

Answer 29

heart problems Epi pen Asthma prolong anesthetic

Question 30

norepinephrine (Direct-Acting Non selective agonist)

Answer 30

hypotension (low blood pressure) vasodilatory shock- septic shock and neurogenic shock

Question 31

Isoprenaline (Direct- Acting Non selective agonist)

Answer 31

Emergency for cardiac arrest, hypovolemic shock, septic shock. congestive heart failure asthma

Question 32

Phenylephrine (direct-Acting selective a1 agonist)

Answer 32

hemorrhoids and Vasopressor: increase in blood pressure

Question 33

Clonidine (direct-acting selective a2 agonist)

Answer 33

hypertension: lower blood pressure IBS psychiatric disorders

Question 34

Dobutamine (Direct-Acting selective b1 Agonist)

Answer 34

increase contractility cardiac output

Question 35

Albuterol (direct acting selective b2 Agonist)

Answer 35

less ca2+ resulting in less muscle contraction. allergic asthma rescue inhaler chronic obstructive pulmonary disease

Question 36

Mixed Acting Non-selective Agonist: Ephedrine

Answer 36

raises systolic and diastolic blood pressure by vasoconstriction and cardiac stimulation Hypotension asthma enhancement on sleep decrease motion sickness

Question 37

what are the three types of antagonists on adrenergic receptors?

Answer 37

a receptor antagonist, b receptor antagonist, a &b receptor antagonist.

Question 38

phenyoxybenzamine

Answer 38

nonselective a receptor blocker of a1 and a2. hypertension

Question 39

-zosin ANYTHING ENDING IN ZOSIN

Answer 39

selective a1 receptor blocker for adrenergic receptor. *on exam*

Question 40

this is a a1 blocker, is a first choice for patients with both hypertension and prostatic hyperplasia.

Answer 40

prazosin. *said is gonna be on the exam*

Question 41

What are the b Blockers of adrenergic receptors known as? all of them end in olol

Answer 41

THE GENERATIONS. first gen second gen- b1 selective third gen- nonselective and b1 selective

Question 42

1st gen non selective drugs

Answer 42

Propanolol (POPSTNolol) Oxprenolol Pindolol Sotalol Timolol Nadolol

Question 43

2nd gen b1- selective drugs

Answer 43

metoprolol (maabeolol2) acebutolol atenolol Bisoprolol Esmolol

Question 44

3rd gen nonselective

Answer 44

CCL Carteolol Carvedilol- also block a1 Labetalol- also block a1

Question 45

3rd gen b1-selective

Answer 45

BN Betaxolol Nebivolol

Question 46

what is the only a2 selective antagonist on adrenergic a receptors.

Answer 46

Yohimbine

Question 47

metoprolol

Answer 47

2nd gen beta blocker blocks the action of epinephrine and norepinephrine at b1 adrenergic receptor.

Question 48

Paroxetine, Fluoxetine, Sertraline

Answer 48

SSRI, Serotonin Transport, Depression

Question 49

Desvenlafaxine

Answer 49

SNRI, serotonin or norepinephrine transporter, Depression

Question 50

Venlafaxine and Duloxetine

Answer 50

SNRI, serotonin or norepinephrine transporter, depression AND anxiety

Question 51

Levomilnacipran

Answer 51

SNRI, serotonin or norepinephrine transporter, depression

Question 52

Phenelzine

Answer 52

MAOI, monoamine oxidase, depression and anxiety

Question 53

Cyproheptadine

Answer 53

Antagonist, 5-HT2 receptor. Serotonin syndrome

Question 54

What is the only thing that is synthesized by tryptophan

Answer 54

serotonin.