Dopamine

Question 1

Dopamine

Class

Answer 1

Sympathomimetic, Inotropic Agent

Question 2

Dopamine

Mechanism of Actions

Answer 2

Immediate metabolic precursor to norepinephrine.

Increases systemic vascular resistance.

Causes peripheral vasoconstriction, but dilates renal vasculature at low doses.

Increases myocardial contractility and stroke volume.

Question 3

Dopamine

Indications

Answer 3

Cardiogenic, septic or spinal shock, hypotension, with low cardiac output states and distributive shock

Question 4

Dopamine

Contraindicaitons

Answer 4

Hypovolemic shock, pheochromocytoma, tachyarrhythmias, V-Fib

Question 5

Dopamine

Adverse reactions:

Answer 5

Cardiac Arrhythmias, hypertension, increased myocardial oxygen demand, extravasation may cause tissue necrosis

Question 6

Dopamine

Drug Interactions with alkaline solution

Answer 6

Incompatible with alkaline solutions.

Question 7

Dopamine

Adult Dosage

Answer 7

IV infusion at 2 – 20 mcg/kg/min titrated to effect.

400 mg in 250 ml ( or 800mg/500ml or 1600mg/1000mL)

Question 8

Dopamine

Pediatric Dosage

Answer 8

2 – 20 mcg/kg/min titrated to effect

Question 9

Dopamine

Onset

Answer 9

Onset

1-4 minutes

Question 10

Dopamine

Peak effects

Answer 10

5-10 minutes

Question 11

Dopamine

Duration

Answer 11

Effects stop almost immediately after infusion is stopped

Question 12

Dopamine

Dose that dilates vessels in kidneys and increases urine output

Answer 12

2-5 mcg/kg/min

Question 13

Dopamine

Dose that increases the heart rate (beta effects)

Answer 13

5-10mcg/kg/min

Question 14

Dopamine

Dose that has primarily vasoconstriction (alpha effects)

Answer 14

10-20mcg/kg/min45

Question 15

Dopamine

Effects with MAOIs

Answer 15

MAOIs will enhance the effects of dopamine.

Question 16

Dopamine

Effects with Beta Blockers

Answer 16

Beta-Blockers may antagonize the effects of dopamine.

Question 17

Dopamine

Interactions with phenytoin (dilantin)

Answer 17

May cause hypotension, bradycardia and seizures.