DNA Viruses Flashcards
LO #1 dsDNA vs ssDNA viruses and structure:
What is the importance of Latency
Infected cells are not recognized by CD8+ T cells and virus is not replicating so antivirals do not work
Parvoviridae - characteristics
- ssDNA (only one)
- small, naked icosahedral
- B19, infects erthyroblasts via erthyrocyte P antigen
- replicates during mitosis and lyses cells to spread
Parvoviridae - clinical disease
Erythema infectiosum (5th disease)
Aplastic anemia
Arthritis
- Phase 1 cold-like symptom
-Phase 2 skin rash, slapped cheek
Parvoviridae - Treatment
Treat cold symptoms, not rash
RBC for anemia
No vaccine
Adenoviridae - characteristics
dsDNA, no envelope, icosahedral
* Receptor = coxsackievirus adenovirus receptor (CAR)
* mucosal cells Upper Resp.
Adenoids
Adenoviridae - clinical
*Leading cause of pharyngitis
*Conjunctivitis after swimming pools - not killed by Cl-
Types 4,7,14 causes sever lower resp. disease (military camps)
Adenoviridae - treatment
Self-resolves
*Cidofovir – for severe infections in weak (Monophosphate cytidine analogue)
* Live, nonattenuated given to military
Papillomaviridae - char.
Naked, icosahedral, dsDNA virus
*Epithelial cells/mucosa
*Causes papillomas (benign tumors)
* Lytic infection in permissive/ transform in non-permissive
HPV skin shedding
Infects basal cells, forms warts in granulosum and spinosum
Papillomaviridae- clinical
Cutaneous warts, genital warts (Type 6 & 11), Carcinoma (16 & 18)
* infected cells called koliocytes and have halo
Papillomaviridae- treatment
Nine-valent vaccine, yeast cells express capsid, L1 viral protein
Polyomaviridae - char
naked, icosahedral dsDNA
*JC and BK viruses (90% adults)
* Transmission= resp, fecal/oral
*Encodes early T antigens that Transform
* late genes = capsid protein
