DNA Replication 3

Question 1

Termination of replication occurs at _________ _____ in eukaryotes.
When ____________ meet, the ___ complexes move past each other on the ________ strand.
As the ____________ move past each other, a flap of _____ ___________ DNA is displaced.
The flaps are resolved by the same machinery that processes ___________ _____________.
This leaves the double-stranded DNA entwined, which is resolved by _______________ ___.

Answer 1

Termination of replication occurs at multiple sites in eukaryotes.
When replisomes meet, the CMG complexes move past each other on the leading strand.
As the replisomes move past each other, a flap of newly synthesised DNA is displaced.
The flaps are resolved by the same machinery that processes Okazaki fragments.
This leaves the double-stranded DNA entwined, which is resolved by topoisomerase II.