DNA Protection

Question 1

Photosomes

Answer 1

1. rare, photo-activated enzyme (photolyase from blue-green algae) encapsulated in a liposome
2. light-activated repair of DNA damage induced by UV
3. photolyase repairs DNA damage & restores skin’s
   immune response; reduces erythema
4. test/proof:
   -in vivo at 1% prevents erythema & restores immune
   response
   -in vivo at 1%: increases amount of time in sun before
   sunburn
   -0.5% reduces photoaging by reducing MMP-1