DNA and meiosis Flashcards
Base structure
Single ring: Cytosine, Thymine Double ring: Guanine, Adenine Pairs: C&G, A&T
Organic base bonds
A&T two hydrogen bonds
C&G three hydrogen bonds
Nucleotide structure
Phosphate group
Deoxyribose
Organic base
Direction of the polynucleotides
They run antiparallel to each other
DNA adaptations for function
- Hydrogen bonds give stability en masse, but are easy to seperate for replication and protein synthesis
- Very stable so it can be passed for generations without change
- Extremely large to carry an immense amount of genetic information
- The helical cylinder of the deoxyribose-phosphate backbone protects the base pairs from corruption by physical/chemical forces
Triplet Code- how it was calculated
- There are 20 amino acids and four bases which can code for these bases
- If pairs of bases coded for amino acids, only 16 amino acids could exist (4x4)
- Therefore three base combinations must code fore amino acids as this gives a potential of 64 (4x4x4) codes.
- Some amino acids must therefore have more than one code
Eukaryotic nuclear DNA
Eukaryotes have large, linear DNA molecules. They associate with proteins to form chromosomes. Much of it does not code for amino acids and these sections are called introns. They occur within genes and as repeats between genes
Start and stop codes
There is one start code amino acid, methionine
THere are three stop codes which mark teh end of a polypeptid chain
Reading the code
It is non-overlapping, so each base is read only once. eg/ 1234567 is read as 123, 456, while 7 does not form an amino acid. It is univeral, so it is the same in all organisms.
Genes and alleles
A gene is a characteristic, such as eye colour. An allels is the version of the gene, such as blue and brown.
Prokaryotic vs Eukaryotic DNA
- Prokaryotes do not conain chromosomes as their DNA forms a cirlce and is not associated with protein molecules
- Eukaryotes have larger, linear DNA molecules. They associate with proteins to form chromosomes
Homologous Chromosomes
Gaining 23 chromosomes from each parent gives us the diploid number (46 in humans). Each one from the egg is a pair to one form the sperm, and this is called a homologous pair.
Chromosome structure
Meiosis definiton
Produces four daughter nuclei, each with half the number of chromosomes as the parent cell. These are gametes.
Independant segregation
The combination of chromosomes in a daughter cell is random as the homologous pairs line up randomly.