DNA Alterations In Cancer

Question 1

What percentage of DNA in a chromosome represents genes?

Answer 1

3%

Question 2

Certain chromosomal translocations are easily detected by what type of method?

Answer 2

Fluorescent in Situ Hybridisation (FISH)

Question 3

Amplifications are only seen in cancer cells. What is the -fold multiplication a small region of chromosome?

Answer 3

5 to 100-fold multiplication.

Question 4

Define amplicons.

Answer 4

Contain one or more gene that enhance proliferation.