DMARDs BRMs Flashcards
Medications that therapeutically alter a patient’s immune response to malignant tumor cells
Immunomodulating
promote the synthesis of various types of major blood
Hematopoietic
increases WBC levels: wait 24 hrs
Filgrastim
CSFs
Platelet-promoting drugs; stimulates bone marrow
Oprelvekin
When severely anemic give:
Epoetin alfa
Longer acting form of filgrastim
pegfilgrastim
Indicated for the prevention of chemotherapy-induced severe thrombocytopenia and avoidance of the need for platelet transfusions
oprelvekin
advantage of hematopoietic drugs
to manage anemia; neutropenia; thrombocytopenia
Hematopoietic Drugs:Adverse Effects
Fever
Muscle aches
Bone p!
Flushing
Interferons indications
Viral infections: warts hepatitis
Autoimmune: MS; RA
Monoclonal Antibodies treat
RA, MS
“mumab”
Interferons adverse effects
Dose-limiting adverse effects is fatigue
Monoclonal Antibodies targets
cancer cells instead minimal effects on healthy cells
Antirehumatic drug:
methotrexate
Used to treat RA
Abatacept (Orencia)
Hydroxychloroquine
Abatacept: must be
up to date on immunizations-do not give live vaccines
Etanercept (Enbrel) &
latex allergy
contraindicated for hepatitis & tTB
Takes 3 to 6 weeks for onset of antirheumatic action
methotrexate
condition that results from inappropriate uric acid metabolism
Gout
Gout drugs
allopurinol (control uric acid in blood; prevention)
Colchicine (acute treatment; short term management)
Allopurinol watch out for
tumor lysis syndrom
SJ syndrome
toxic epidermal necrolysis
Allopurinol watch for also:
renal stones; monitor uric acid levels
Treatment of cancer, rheumatoid arthritis (RA), MS, and organ transplantation
Specifically target cancer cells and have minimal effect on healthy cells
monoclonal antibodies
Etanercept (Enbrel) &
Contraindicated in presence of active infections
Reactivation of hepatitis and tuberculosis has been reported.
